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Standard: Human gastric cancer organoids

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机构: [1]Guangzhou National Laboratory, Guangzhou 510005, China. [2] The State Key Laboratory of Membrane Biology, Tsinghua‑Peking Center for Life Sciences,, School of Life Sciences, Tsinghua University, Beijing 100084, China. [3] The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang 330031, China. [4] Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China. [5] State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China. [6] Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, Guangzhou 510060, China. [7]State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Gastrointestinal Oncology, Beijing Key Laboratory of Carcinogenesis and Translational Research, Peking University Cancer Hospital & Institute, Beijing 100142, China. [8] State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Shanghai Jiaotong University School of Medicine, Shanghai 200232, China. [9] Department of Biliary‑Pancreatic Surgery, Renji HospitalAffiliated to, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China. [10] MOE Key Laboratory of Cellular Dynamics, CAS Center for Excellence in Molecular Cell Science, University of Science and Technology of China, Hefei 230027, China. [11] Key Laboratory of Multi‑Cell Systems, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China. [12] University of Chinese Academy of Sciences, Beijing 100049, China. [13] Institute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen 518132, China. [14] Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330031, China. [15] Jiangxi Key Laboratory for Individual Cancer Therapy, Nanchang, Jiangxi 330031, China. [16] School of Life Science and Technology, Shanghai Tech University, Shanghai 201210, China. [17] State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Science, Shanghai 200031, China. [18] Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, 155N Nanjing Street, Shenyang, Liaoning 110001, China. [19] Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, China Medical University, Shenyang, Liaoning 110001, China. [20] Institute of Health Sciences, China Medical University, Shenyang, Liaoning 110001, China. [21] National Stem Cell Resource Center, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. [22] State Key Laboratory of Stem Cell and Reproductive Biology, Institute for Stem Cell and Regeneration, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. [23] Department of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China. [24] Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Protection, Suzhou Medical College, Soochow University, Suzhou 510080, China. [25] National Institute of Metrology, Beijing 100029, China. [26] Department of Radiation Oncology and Cancer Institute, Fudan University Shanghai Cancer Center Fudan University, Shanghai 200433, China. [27] D1Med Technology (Shanghai) Inc, Shanghai 201802, China. [28] Gastric Cancer Centerand, Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China. [29] Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Center for Cancer Bioinformatics, Peking University Cancer Hospital & Institute, Beijing 100142, China [30] Peking University International Cancer Institute, Peking University, Beijing 100191, China. [31] China National Institute of Standardization, Beijing 100191, China. [32] Institute of Clinical Science, Zhongshan Hospital, Fudan University, Shanghai 200433, China. [33] Department of Gastrointestinal Pathology, Ningbo Diagnostic Pathology Center, Ningbo 315021, China. [34] Department of Oncology, Changhai Hospital, Second Military Medical University, No. 168 Changhai Road, Shanghai 200433, China. [35] Huayi Regeneration Technology Co., Ltd, Chengdu 611135, China. [36] K2 Oncology Co., Ltd, KeChuang Street, Beijing 100176, China. [37] Lilly (China) Research and Development Center, Shanghai 201203, China. [38] Qilu Pharmaceutical Co., Ltd, Jinan 250104, China. [39] Shanghai OneTar Biomedicine Co., Ltd, Shanghai 201203, China.
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关键词: Standard Human stomach Gastric cancer organoids Terms Definitions Technical requirements Labeling Transportation Storage

摘要:
Gastric cancer is one of the most common malignancies with poor prognosis. The use of organoids to simulate gastric cancer has rapidly developed over the past several years. Patient-derived gastric cancer organoids serve as in vitro models that closely mimics donor characteristics, offering new opportunities for both basic and applied research. The "Human Gastric Cancer Organoid" is part of a series of guidelines for human gastric cancer organoids in China, jointly drafted by experts from the Chinese Society for Cell Biology and its branches, and initially released on October 29, 2024. This standard outlines terminology, technical requirements, assessment protocols, and applies to production, evaluation procedures, and quality control for human gastric cancer organoids. The publication of this guideline aims to assist institutions in endorsing, establishing, and applying best practices, advancing the international standardization of human gastric cancer organoids for clinical development and therapeutic application.© 2024. The Author(s).

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第一作者机构: [1]Guangzhou National Laboratory, Guangzhou 510005, China.
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通讯机构: [1]Guangzhou National Laboratory, Guangzhou 510005, China. [2] The State Key Laboratory of Membrane Biology, Tsinghua‑Peking Center for Life Sciences,, School of Life Sciences, Tsinghua University, Beijing 100084, China. [3] The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang 330031, China. [4] Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China. [21] National Stem Cell Resource Center, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. [22] State Key Laboratory of Stem Cell and Reproductive Biology, Institute for Stem Cell and Regeneration, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
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