Purpose. The purpose of this study is to discuss the effect of an intervention measure combining oncology, psychology, and sociomedicine on survival and quality of life in cancer patients. Methods. 639 cases of malignant tumor were divided into intervention and control groups. Follow-up was completed on 254 cases in the intervention group (93.38%) and 330 cases in the control group (89.91%). The intervention consisted of systematic mass anticancer education and rehabilitation activities guided by specialists over the period of 2 years, while the control group was in a state of self-rehabilitation. Differences between groups in survival status and survival rate for different disease stages were reviewed after 2 years. Survival status was evaluated by the Cox proportional hazards model. Results. Statistical analysis of survival was controlled for sociological variables such as marriage and age. The 2-year survival in stage 2 patients was 94.84% (108/114) in the intervention group and 80.67% (121/150) in the control group. There was a striking and significant (P <.01) difference in 2-year survival rates. Further analysis disclosed that 2-year survival rate for early- and medium-stage patients was 88.03% (163/177) in the intervention group and 82.8% (184/222) in the control group. Conclusion. An intervention including oncology, psychology, and sociomedicine improved 2-year survival rate in early and middle stages of malignant tumor. © 2008 Sage Publications.