机构：[1]Department of Head and Neck Surgery[2]Department of Oral and Maxillary Surgery The Affiliated Hospital Guiyang Medical College Guiyang 550004
出处：
ISSN：
摘要：
Objective: To study the expression and the significance of Angiopoietin-1 (Ang-1) through observing the correlations among the expression of Ang-1 to clinicopathologic characteristics and microvessel density (MVD) in oral squamous cell carcinoma (OSCC). Methods: Expressions of Angiopoietin-1 and CD34 in 41 human OSCC tissues, 30 adjacent noncancerous oral tissues and 10 normal oral mucosas were detected by immunohistochemical SABC method. MCD was also assessed. Results: Of the 41 OSCC tissues, 41.46% (17/41) was Ang-1 positive. The expression of Ang-1 was significantly lower in OSCC than that in adjacent noncancerous oral tissues (P(0.05) and normal oral mucosa (P(0.05). The Ang-1 expression was significantly higher in high differentiated tumor than that in moderately differentiated tumor (P(0.05). The MVD was significantly higher in Ang-1-negative OSCC than in Ang-1-positive OSCC (P(0.01), and negatively correlated with the expression of Ang-1 (r=-0.32, P(0.05). Conclusion: Down-regulated expression of Ang-1 may play a crucial role in the development of OSCC. It negatively regulated the angiogenesis of tumor.
基金：
This work was supported by the Medical Science Grant of Sichuan Province Key Sci & Tech Subjects (No. 20020807) and Guizhou Province Government Century Grant (No.9813).；
语种：
外文
中科院(CAS)分区：
出版当年[2006]版：
无
最新[2023]版：
大类|2 区医学
小类|3 区肿瘤学
第一作者：
第一作者机构：[1]Department of Head and Neck Surgery
通讯作者：
推荐引用方式(GB/T 7714)：
李超,陈建超,王朝晖,et al.CORRELATIONS AMONG EXPRESSION OF ANGIOPOIETIN-1 TO CLINICAL PATHOLOGICAL CHARACTERISTICS AN ANGIO-GENESIS IN ORAL SQUAMOUS CELL CARCINOMA[J].CHINESE JOURNAL OF CANCER RESEARCH.2006,18(3):198-202.
APA：
李超,陈建超,王朝晖,张兵,李彬&宋宇峰.(2006).CORRELATIONS AMONG EXPRESSION OF ANGIOPOIETIN-1 TO CLINICAL PATHOLOGICAL CHARACTERISTICS AN ANGIO-GENESIS IN ORAL SQUAMOUS CELL CARCINOMA.CHINESE JOURNAL OF CANCER RESEARCH,18,(3)
MLA：
李超,et al."CORRELATIONS AMONG EXPRESSION OF ANGIOPOIETIN-1 TO CLINICAL PATHOLOGICAL CHARACTERISTICS AN ANGIO-GENESIS IN ORAL SQUAMOUS CELL CARCINOMA".CHINESE JOURNAL OF CANCER RESEARCH 18..3(2006):198-202
