Clinical Benefit of Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors Plus Radiotherapy for Epidermal Growth Factor Receptor-Mutated Metastatic Non-Small Cell Lung Cancer: A Retrospective Analysis on Real World Data
机构:[1]Department of Oncology,The Affiliated Hospital of Southwest Medical University,Luzhou 646000,Sichuan,China[2]Department of Radiation Oncology,Sichuan Cancer Hospital & Institute,Sichuan Cancer Center,School of Medicine,University of Electronic Science and Technology of China, Chengdu 610041,China四川省肿瘤医院[3]Department of Symptom Research,The University of Texas MD Anderson Cancer Center,1515 Holcombe Blvd. Houston,Texas 77030,USA
Objective: To investigate the benefit of epidermal growth factor receptor( EGFR) tyrosine kinase inhibitors( TKIs)with radiotherapy in patients with EGFR mutation-positive metastatic non-small cell lung cancer( NSCLC),compared with TKIs alone.Methods: A total of 103 patients with stage Ⅳ EGFR-mutated NSCLC treated from February 2015 to May 2017 at Sichuan Cancer Hospital were analyzed retrospectively. Fifty patients were treated with EGFR-TKIs( gefitinib or erlotinib) plus radiotherapy( the TKI +RT group) and 53 patients received EGFR-TKIs alone( the TKI group). Tumor response,survival and toxicities were compared between the two groups. Results: Median follow-up time was 11. 7 months( 2. 8-36. 3 months). The overall response rate( ORR) and disease control rate( DCR) in the TKI + RT group vs the TKI group were 62% vs 37. 7%( P = 0. 014) and 88% vs 75. 5%( P =0. 101),respectively. The median progression-free survival( PFS) and median overall survival( OS) in the TKI + RT group were superior to those of the TKI group( 18. 87 months vs 12. 80 months,P = 0. 035 and 23. 10 months vs 18. 30 months,P = 0. 011). OS rates in the TKI + RT group and the TKI group were 56. 0% vs 35. 8% at year 1( P = 0. 04) and 16. 0% vs 3. 8% at year 2( P =0. 036). Multivariate Cox model found that TKI + RT related to significantly better OS( hazard ratio = 0. 209; 95% CI,0. 066 to0. 661; P = 0. 008) than TKI alone. Adverse events did not differ significantly between the two groups( P ) 0. 050). Conclusion:Compared with EGFR-TKIs alone,EGFR-TKIs combined with radiotherapy was well tolerated and showed benefit in tumor response and survival for EGFR mutation-positive metastatic NSCLC patients.
基金:
supported by Wu Jieping Medical Foundation(NO.320.6750.14273);
基金编号:NO.320.6750.14273
语种:
外文
第一作者:
第一作者机构:[1]Department of Oncology,The Affiliated Hospital of Southwest Medical University,Luzhou 646000,Sichuan,China[2]Department of Radiation Oncology,Sichuan Cancer Hospital & Institute,Sichuan Cancer Center,School of Medicine,University of Electronic Science and Technology of China, Chengdu 610041,China
通讯作者:
通讯机构:[1]Department of Oncology,The Affiliated Hospital of Southwest Medical University,Luzhou 646000,Sichuan,China[2]Department of Radiation Oncology,Sichuan Cancer Hospital & Institute,Sichuan Cancer Center,School of Medicine,University of Electronic Science and Technology of China, Chengdu 610041,China[3]Department of Symptom Research,The University of Texas MD Anderson Cancer Center,1515 Holcombe Blvd. Houston,Texas 77030,USA
推荐引用方式(GB/T 7714):
Wang Ranlin,Li Tao,Lv Jiahua,et al.Clinical Benefit of Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors Plus Radiotherapy for Epidermal Growth Factor Receptor-Mutated Metastatic Non-Small Cell Lung Cancer: A Retrospective Analysis on Real World Data[J].Journal of Cancer Control and Treatment.2019,(5):385-394.doi:10.3969/j.i
ssn.1674-0904.2019.05.002
.
APA:
Wang Ranlin,Li Tao,Lv Jiahua,Sun Chang&Shi Qiuling.(2019).Clinical Benefit of Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors Plus Radiotherapy for Epidermal Growth Factor Receptor-Mutated Metastatic Non-Small Cell Lung Cancer: A Retrospective Analysis on Real World Data.Journal of Cancer Control and Treatment,,(5)
MLA:
Wang Ranlin,et al."Clinical Benefit of Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors Plus Radiotherapy for Epidermal Growth Factor Receptor-Mutated Metastatic Non-Small Cell Lung Cancer: A Retrospective Analysis on Real World Data".Journal of Cancer Control and Treatment ..5(2019):385-394