机构：[1]Department of Gynecological Oncology, Second People’s Hospital of Sichuan (Sichuan Cancer Hospital), Sichuan 610041, People’s Republic of China四川省肿瘤医院[2]School of Biomedical Sciences, The University of Queensland, Brisbane QLD 4072, Australia[3]Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Sichuan 610041, People’s Republic of China
Estrogen plays several important physiological and pathological functions in not only reproductive system but many other systems as well. Its transcriptional activation has been traditionally described as being mediated by classic nuclear estrogen receptors (ERs). It is however established recently that a novel functional estrogen transmembrane receptor, G protein-coupled receptor 30 (GPR30), modulates both rapid non-genomic events and genomic transcriptional events of estrogen. It has been demonstrated that GPR30 promotes the progress of estrogen-related tumors through mitogen-activated protein kinase (MAPK) signaling pathways. Effects mediated by GPR30 are maintained when classic ERs are absent or blocked. In addition, GPR30 is involved in drug resistance, which is often occurring during cancer treatments. All these new findings strongly imply that GPR30 may be an important therapeutic target for estrogen-related tumors. Simultaneously blocking both GPR30 and classic ERs may be a better strategy for the treatment of estrogen-related tumors.
基金：
Australian NHMRC, University of Queensland. DF Wang is a recipient of
postgraduate research scholarship from the Chinese Scholarship
Council (CSC, China) and subsidy scholarship by the University of
Queensland
第一作者机构：[1]Department of Gynecological Oncology, Second People’s Hospital of Sichuan (Sichuan Cancer Hospital), Sichuan 610041, People’s Republic of China[2]School of Biomedical Sciences, The University of Queensland, Brisbane QLD 4072, Australia
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Dengfeng,Hu Lina,Zhang Guonan,et al.G protein-coupled receptor 30 in tumor development[J].ENDOCRINE.2010,38(1):29-37.doi:10.1007/s12020-010-9363-z.
