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Estrogen and BRCA1 deficiency synergistically induce breast cancer mutation-related DNA damage.

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资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Chen Jiahao[1,3] ; Liu Jingxin[1,3] ; Zeng Pengguihang[3] ; Zhao Cai[3] ; Liu Xinyi[3] ; Sun Jun[3] ; Wang Jia[3,4] ; Fang Peihang[3] ; Chen Wenjie[1,*1] ; Ding Junjun[1,2,3,5,*1] ;
机构： [1]Vaccine Research Institute, The Third Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou, 510630, China [2]Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510630, China [3]Department of Cell Biology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China [4]Guangzhou Medical University-Guangzhou Institute of Biomedicine and Health Joint School of Life Sciences, Guangzhou Medical University, Guangzhou, 511436, China [5]West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, 610041, China
出处：
DOI： 10.1016/j.bbrc.2022.04.142
ISSN：

关键词： Breast cancer BRCA1 Estrogen DNA Damage Estrogen receptor-a

摘要：
Estrogen (E2) is crucial for the development of breast cancer caused by BRCA1 mutation, and can increase the DNA damage in BRCA1-deficient cells. However, the mechanisms through which BRCA1 deficiency and E2 synergistically induce DNA damage remains unclear. In this study, we analyzed the distribution of DNA damage in E2-treated BRCA1-deficient cells. We detected DNA lesions in the vicinity of genes that are transcriptionally activated by estrogen receptor-α (ER). Loss of BRCA1 altered chromatin binding by ER, which significantly affected the distribution of DNA damage. Moreover, these changes were associated with the established mutations in BRCA1-mutant breast cancer. Taken together, our findings reveal a new mechanism underlying the DNA damage in breast cancer cells that is synergistically induced by BRCA1 deficiency and E2.Copyright © 2022 Elsevier Inc. All rights reserved.

基金：
National Key Research and Development Program (2017YFA0102800), the National Natural Science Foundation of China (Grant Nos. 31970811, 31771639 and 32170798), the Guangdong Innovative and Entrepreneurial Research Team Program (2016ZT06S029), Guangdong Basic and Applied Basic Research Foundation (2021B1515120063), the Guangdong Regenerative Medicine and Health of Guangdong Laboratory Frontier Exploration Project (2018GZR110105007) to J. D.. The Natural Science Foundation of Guangdong Province, China (2021A1515010938) to J.S..
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 4 区 生物学
小类 | 4 区 生化与分子生物学 4 区 生物物理
最新[2023]版：
大类 | 3 区 生物学
小类 | 3 区 生物物理 4 区 生化与分子生物学
JCR分区：
出版当年[2022]版：
Q2 BIOPHYSICS Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版：
Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Vaccine Research Institute, The Third Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou, 510630, China [3]Department of Cell Biology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China
共同第一作者：
通讯作者：
通讯机构： [1]Vaccine Research Institute, The Third Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou, 510630, China [2]Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510630, China [3]Department of Cell Biology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China [5]West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, 610041, China [*1]Vaccine Research Institute, The Third Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou, 510630, China
推荐引用方式(GB/T 7714)：
Chen Jiahao,Liu Jingxin,Zeng Pengguihang,et al.Estrogen and BRCA1 deficiency synergistically induce breast cancer mutation-related DNA damage.[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2022,613:140-145.doi:10.1016/j.bbrc.2022.04.142.
APA：
Chen Jiahao,Liu Jingxin,Zeng Pengguihang,Zhao Cai,Liu Xinyi...&Ding Junjun.(2022).Estrogen and BRCA1 deficiency synergistically induce breast cancer mutation-related DNA damage..BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,613,
MLA：
Chen Jiahao,et al."Estrogen and BRCA1 deficiency synergistically induce breast cancer mutation-related DNA damage.".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 613.(2022):140-145

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