Comparison of the Masaoka-Koga staging and the International Association for the Study of Lung Cancer/the International Thymic Malignancies Interest Group proposal for the TNM staging systems based on the Chinese Alliance for Research in Thymomas retrospective database
机构：[1]Department of Thoracic Surgery, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China河南省肿瘤医院[2]Department of ThoracicSurgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China[3]Department of Thoracic Surgery, GuangdongEsophageal Cancer Institute, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative InnovationCenter of Cancer Medicine, Guangzhou 510060, China[4]Department of Thoracic Surgery, Affiliated Hospital of Qingdao University, Qingdao266001, China[5]Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China[6]Department of Endocrinology,Tianjin Medical University General Hospital, Tianjin 300052, China[7]Department of Thoracic Surgery, Sichuan Cancer Hospital, Chengdu 610041,China外科中心胸外科中心四川省肿瘤医院胸外科[8]Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou 350001, China[9]Department of Thoracic Surgery,First Affiliated Hospital of Anhui Medical University, Hefei 230022, China[10]Department of Thoracic Surgery, Beijing Cancer Hospital, Beijing100142, China[11]Department of Cardiothoracic Surgery, Changhai Hospital, Shanghai 200433, China[12]Department of Thoracic Surgery, LiaoningCancer Hospital, Shenyang 110042, China[13]Department of Thoracic Surgery, First Affiliated Hospital of Jilin University, Changchun 130021,China[14]Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China四川大学华西医院[15]Department of Thoracic Surgery,Huashan Hospital, Fudan University, Shanghai 200032, China[16]Department of Esophageal Cancer, Tianjin Cancer Hospital, Tianjin 300060,China[17]Department of Thoracic Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, China浙江省肿瘤医院[18]Department of Thoracic Surgery, Jiangxi People’sHospital, Nanchang 330006, China
Background: To compare the predictive effect of the Masaoka-Koga staging system and the International Association for the Study of Lung Cancer (IASLC)/the International Thymic Malignancies Interest Group (ITMIG) proposal for the new TNM staging on prognosis of thymic malignancies using the Chinese Alliance for Research in Thymomas (ChART) retrospective database. Methods: From 1992 to 2012, 2,370 patients in ChART database were retrospectively reviewed. Of these, 1,198 patients with complete information on TNM stage, Masaoka-Koga stage, and survival were used for analysis. Cumulative incidence of recurrence (CIR) was assessed in R0 patients. Overall survival (OS) was evaluated both in an R0 resected cohort, as well as in all patients (any R status). CIR and OS were first analyzed according to the Masaoka-Koga staging system. Then, they were compared using the new TNM staging proposal. Results: Based on Masaoka-Koga staging system, significant difference was detected in CIR among all stages. However, no survival difference was revealed between stage I and II, or between stage II and III. Stage IV carried the highest risk of recurrence and worst survival. According to the new TNM staging proposal, CIR in T1a was significantly lower comparing to all other T categories (P<0.05) and there was a significant difference in OS between T1a and T1b (P=0.004). T4 had the worst OS comparing to all other T categories. CIR and OS were significantly worse in N (+) than in N0 patients. Significant difference in CIR and OS was detected between M0 and M1b, but not between M0 and M1a. OS was almost always statistically different when comparison was made between stages I-IIIa and stages IIIb-IVb. However, no statistical difference could be detected among stages IIIb to IVb. Conclusions: Compared with Masaoka-Koga staging, the IASLC/ITMIG TNM staging proposal not only describes the extent of tumor invasion but also provides information on lymphatic involvement and tumor dissemination. Further study using prospectively recorded information on the proposed TNM categories would be helpful to better grouping thymic tumors for predicting prognosis and guiding clinical management.
第一作者机构：[1]Department of Thoracic Surgery, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Thoracic Surgery, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China[2]Department of ThoracicSurgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China[*1]Department of Thoracic Surgery, Affiliated Cancer Hospital of Zhengzhou University, 127 Dongming Road, Zhengzhou 450008, China.[*2]Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, 241 Huaihai Road West, Shanghai 200030, China.
推荐引用方式(GB/T 7714)：
Liang Guanghui,Gu Zhitao,Li Yin,et al.Comparison of the Masaoka-Koga staging and the International Association for the Study of Lung Cancer/the International Thymic Malignancies Interest Group proposal for the TNM staging systems based on the Chinese Alliance for Research in Thymomas retrospective database[J].JOURNAL OF THORACIC DISEASE.2016,8(4):727-737.doi:10.21037/jtd.2016.03.22.
APA：
Liang, Guanghui,Gu, Zhitao,Li, Yin,Fu, Jianhua,Shen, Yi...&Fang, Wentao.(2016).Comparison of the Masaoka-Koga staging and the International Association for the Study of Lung Cancer/the International Thymic Malignancies Interest Group proposal for the TNM staging systems based on the Chinese Alliance for Research in Thymomas retrospective database.JOURNAL OF THORACIC DISEASE,8,(4)
MLA：
Liang, Guanghui,et al."Comparison of the Masaoka-Koga staging and the International Association for the Study of Lung Cancer/the International Thymic Malignancies Interest Group proposal for the TNM staging systems based on the Chinese Alliance for Research in Thymomas retrospective database".JOURNAL OF THORACIC DISEASE 8..4(2016):727-737
