机构：[1]Department of Gastrointestinal Surgery & Gastric Cancer Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China/Gastric Cancer Center of Sun Yat-Sen University, Guangzhou, China临床科室胃外科外科科室胃肠外科中心胃肠外科中山大学附属第一医院中山大学肿瘤防治中心[2]Department of Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China[3]Department of Thoracic Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China外科科室胸外科中山大学附属第一医院[4]Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China[5]Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China[6]Department of Clinical laboratory, Cancer Center of Sun Yat-sen University, Collaborative Innovation Center for Cancer Medicine,State Key Laboratory of Oncology in South China, Guangzhou, China临床科室其他部门临床研究部/药物临床试验机构华南肿瘤学国家重点实验室中山大学肿瘤防治中心
Aim: We performed a study to identify the role of microRNA in thymoma. Patients & methods: One hundred twenty-three thymoma patients with clinical information and miRNA expression data from The Cancer Genome Atlas were included in the study. Comprehensive bioinformatics analysis was integrated in our analysis. Results & conclusion: Seven miRNAs were found to be associated with overall survival (p < 0.001). Another four miRNAs were found to be associated with disease-free survival (p < 0.001). Type C thymoma can be distinguished from nontype C thymoma by miRNAs. Interestingly, seven miRNAs showed both prognostic and subtype-specific potential. Our findings suggest that miRNAs can be used for prognostic prediction and subtype stratification.
基金：
National Natural Science Foundation of China [81401307]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|2 区生物
小类|2 区遗传学
最新[2023]版：
大类|4 区医学
小类|4 区遗传学
第一作者：
第一作者机构：[1]Department of Gastrointestinal Surgery & Gastric Cancer Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China/Gastric Cancer Center of Sun Yat-Sen University, Guangzhou, China[2]Department of Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Gastrointestinal Surgery & Gastric Cancer Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China/Gastric Cancer Center of Sun Yat-Sen University, Guangzhou, China
推荐引用方式(GB/T 7714)：
Jiamin Wei,Zhenguo Liu,Kaiming Wu,et al.Identification of prognostic and subtype-specific potential miRNAs in thymoma[J].EPIGENOMICS.2017,9(5):647-657.doi:10.2217/epi-2016-0161.
APA：
Jiamin Wei,Zhenguo Liu,Kaiming Wu,Dongjie Yang,Yulong He...&Jianhua Lin.(2017).Identification of prognostic and subtype-specific potential miRNAs in thymoma.EPIGENOMICS,9,(5)
MLA：
Jiamin Wei,et al."Identification of prognostic and subtype-specific potential miRNAs in thymoma".EPIGENOMICS 9..5(2017):647-657
