机构:[1]Department of Clinical Laboratory, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China 四川省人民医院四川省肿瘤医院[2]Department of Medical Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China 四川省人民医院四川省肿瘤医院[3]Department of Biology, The Northeastern University, Huntington Ave, Boston, MA, USA [4]Radiotherapy Center, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China四川省人民医院四川省肿瘤医院
We retrospectively enrolled 191 nasal-type, extranodal natural killer/T-cell lymphoma (ENKTL) patients newly diagnosed from 2008 to 2016 at the Sichuan Cancer Hospital, in order to evaluate the relationship between disease outcomes, demographic and clinical factors, and red blood cell distribution width (RDW). C-index, fisher's exact test, univariate analysis, and cox regression analysis were applied. The median age of patients was 44 years and 134 (70%) were men. The cutoff of RDW was 46.2 fL determined by Cutoff Finder. Patients with RDW <= 46.2 fL had significantly better progression-free survival (PFS) (3-year PFS, 80.4% vs. 63.1%; P=0.01) and overall survival (OS) (3-year OS, 83.2% vs. 65.5%; P=0.004) than those with RDW>46.2 fL. Multivariate analysis demonstrated that elevated RDW is an independent adverse predictor of OS (P=0.021, HR=2.04). RDW is an independent predictor of survival outcomes in ENKTL, which we found to be superior to both the prognostic index of natural killer lymphoma (PINK) and the Korean Prognostic Index (KPI) in discriminating patients with different outcomes in low-risk and high-risk groups (all P < 0.05). The new models combining RDW with the International Prognostic Index (IPI), KPI, and PINK showed more powerful prognostic value than corresponding original models. RDW represents an easily available and inexpensive marker for risk stratification in patients with ENKTL treated with radiotherapy-based treatment. Further prospective studies are warranted to confirm the prognostic value of RDW in ENKTL.
基金:
Health and Family Planning Commission of Sichuan Province [17PJ516]
第一作者机构:[1]Department of Clinical Laboratory, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China
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推荐引用方式(GB/T 7714):
Luo Huaichao,Quan Xiaoying,Song Xiao-Yu,et al.Red blood cell distribution width as a predictor of survival in nasal-type, extranodal natural killer/T-cell lymphoma[J].ONCOTARGET.2017,8(54):92522-92535.doi:10.18632/oncotarget.21439.
APA:
Luo, Huaichao,Quan, Xiaoying,Song, Xiao-Yu,Zhang, Li,Yin, Yilin...&Yu, Sisi.(2017).Red blood cell distribution width as a predictor of survival in nasal-type, extranodal natural killer/T-cell lymphoma.ONCOTARGET,8,(54)
MLA:
Luo, Huaichao,et al."Red blood cell distribution width as a predictor of survival in nasal-type, extranodal natural killer/T-cell lymphoma".ONCOTARGET 8..54(2017):92522-92535