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Well-defined survival outcome disparity across age cutoffs at 45 and 60 for medullary thyroid carcinoma: a long-term retrospective cohort study of 3601 patients

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机构： [1]Division of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [2]Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, NY, United States. [3]Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, United States. [4]Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States. [5]Institute for Airway Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States. [6]Center for Epithelial and Airway Biology and Regeneration, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

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关键词： medullary thyroid cancer survival analysis age cutoffs well-defined survival disparity outcome predictor

摘要：

Medullary thyroid cancer (MTC) is a challenging malignancy. The survival outcome of MTC based on AJCC staging system does not render a discriminant classifier among early stages.3601 MTC patients from 2000 to 2018 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Smooth curve fitting, Cox proportional hazard regression and competing risk analysis were applied.A linear correlation between age and log RR (relative risk of overall death) was detected. Overlaps were observed between K-M curves representing patients aged 45-50, 50-55, and 55-60. The study cohort was divided into 3 subgroups with 2 age cutoffs set at 45 and 60. Each further advanced age cutoff population resulted in a roughly "5%" increase in MTC-specific death risks and an approximately "3 times" increase in non-MTC-specific death risks.The survival outcome disparity across age cutoffs at 45 and 60 for MTC has been well defined.Copyright © 2024 Zhang, Wang, Wei, Li, Zhu and Chen.

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出版当年[2023]版：

大类 | 2 区医学

小类 | 2 区内分泌学与代谢

最新[2023]版：

大类 | 2 区医学

小类 | 2 区内分泌学与代谢

第一作者：

第一作者机构： [1]Division of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

通讯作者：

通讯机构： [2]Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, NY, United States. [3]Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, United States. [4]Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States. [5]Institute for Airway Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States. [6]Center for Epithelial and Airway Biology and Regeneration, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

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