机构：[1]Department of Radiology, Huaxi MR ResearchCenter (HMRRC), West China Hospital ofSichuan University, Chengdu, Sichuan, China[2]Department of Radiology, Sichuan CancerHospital & Institute, Sichuan Cancer Center,School ofMedicine, University of ElectronicScience and Technology of China, Chengdu, China四川省肿瘤医院[3]Department of Psychiatry and BehavioralNeuroscience, University of Cincinnati,Cincinnati, Ohio[4]Department of Medical Information Engineering,School of Electrical Engineering and Information,Sichuan University, Chengdu, Sichuan, China[5]Mental Health Institute, The Second XiangyaHospital of Central South University,Changsha, Hunan, China[6]Department of Psychology, School of PublicAdministration, Sichuan University, Chengdu,Sichuan, China
To psychoradiologically investigate the topological organization of single-subject gray matter networks in patients with PTSD. Eighty-nine adult PTSD patients and 88 trauma-exposed controls (TEC) underwent a structural T1 magnetic resonance imaging scan. The single-subject brain structural networks were constructed based on gray matter similarity of 90 brain regions. The area under the curve (AUC) of each network metric was calculated and both global and nodal network properties were measured in graph theory analysis. We used nonparametric permutation tests to identify group differences in topological metrics. Relationships between brain network measures and clinical symptom severity were analyzed in the PTSD group. Compared with TEC, brain networks of PTSD patients were characterized by decreased clustering coefficient (C-p) (p = .04) and local efficiency (E-loc) (p = .04). Locally, patients with PTSD exhibited altered nodal centrality involving medial superior frontal (mSFG), inferior orbital frontal (iOFG), superior parietal (SPG), middle frontal (MFG), angular, and para-hippocampal gyri (p < .05, corrected). A negative correlation between the segregation (C-p) of gray matter and functional networks was found in PTSD patients but not the TEC group. Analyses of topological brain gray matter networks indicate a more randomly organized brain network in PTSD. The reduced segregation in gray matter networks and its negative relation with increased segregation in the functional network indicate an inverse relation between gray matter and functional changes. The present psychoradiological findings may reflect a compensatory increase in functional network segregation following a loss of segregation in gray matter networks.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81501452, 81621003, 81761128023, 81220108013, 81227002]; Program for Changjiang Scholars and Innovative Research Team in UniversityProgram for Changjiang Scholars & Innovative Research Team in University (PCSIRT) [IRT16R52]; Changjiang Scholar Professorship Award [T2014190]; CMB Distinguished Professorship Award [F510000/G16916411]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|2 区医学
小类|2 区神经成像2 区神经科学2 区核医学
最新[2023]版：
大类|2 区医学
小类|2 区神经成像2 区神经科学2 区核医学
JCR分区：
出版当年[2018]版：
Q1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ1NEUROSCIENCESQ1NEUROIMAGING
最新[2023]版：
Q1NEUROIMAGINGQ1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ2NEUROSCIENCES
第一作者机构：[1]Department of Radiology, Huaxi MR ResearchCenter (HMRRC), West China Hospital ofSichuan University, Chengdu, Sichuan, China[2]Department of Radiology, Sichuan CancerHospital & Institute, Sichuan Cancer Center,School ofMedicine, University of ElectronicScience and Technology of China, Chengdu, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Radiology, Huaxi MR ResearchCenter (HMRRC), West China Hospital ofSichuan University, Chengdu, Sichuan, China[6]Department of Psychology, School of PublicAdministration, Sichuan University, Chengdu,Sichuan, China[*1]Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China
推荐引用方式(GB/T 7714)：
Niu Running,Lei Du,Chen Fuqin,et al.Reduced local segregation of single-subject gray matter networks in adult PTSD[J].HUMAN BRAIN MAPPING.2018,39(12):4884-4892.doi:10.1002/hbm.24330.
APA：
Niu, Running,Lei, Du,Chen, Fuqin,Chen, Ying,Suo, Xueling...&Gong, Qiyong.(2018).Reduced local segregation of single-subject gray matter networks in adult PTSD.HUMAN BRAIN MAPPING,39,(12)
MLA：
Niu, Running,et al."Reduced local segregation of single-subject gray matter networks in adult PTSD".HUMAN BRAIN MAPPING 39..12(2018):4884-4892
医学