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Upregulation of miRNA-140-5p inhibits inflammatory cytokines in acute lung injury through the MyD88/NF-kappa B signaling pathway by targeting TLR4

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收录情况： ◇ SCIE

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机构： [1]Department of Medical Oncology, Sichuan Cancer Hospital, Chengdu, Sichuan 610041 [2]Department of Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120 [3]Surgical Center, Sichuan Cancer Hospital, Chengdu, Sichuan 610041, P.R. China

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关键词： microRNA-140-5p acute lung injury inflammation Toll-like receptor 4 myeloid differentiation primary response 88 nuclear factor-kappa B

摘要：

The present study was designed to determine the effect of miR-140-5p on acute lung injury (ALI) and the associated inflammation induced. As a result, miR-140-5p expression in mice with ALI was suppressed when compared with the normal group. Downregulation of miR-140-5p increased the levels of inflammatory factors induced by ALI [including tumor necrosis factor-alpha, interleukin (IL)-1 beta, IL-6 and myeloperoxidase] in an in vitro model of human lung A549 cells. Downregulation of miR-140-5p also induced the protein expression of Toll-like receptor 4 (TLR4), myeloid differentiation primary response 88 (MyD88) and nuclear factor (NF)-kappa B in an in vitro model. Overexpression of miR-140-5p reduced the levels of inflammation in the in vitro model of ALI via the suppression of the TLR4/MyD88/NF-kappa B signaling pathway. The inhibition of TLR4 using a TLR4 inhibitor reduced the proinflammation effects of anti-miR-140-5p in the in vitro model of ALI. The NF-kappa B inhibitor also inhibited the proinflammation effects of anti-miR-140-5p in the in vitro model of ALI. Overall, the results of the present study indicated that miR-140-5p inhibited ALI-induced inflammation via the TLR4/MyD88/NF-kappa B signaling pathway.

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出版当年[2018]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验

最新[2023]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验

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出版当年[2018]版：

Q4 MEDICINE, RESEARCH & EXPERIMENTAL

最新[2023]版：

Q3 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 2.4 最新[2023版] 2.3 最新五年平均 1.448 出版当年[2018版] 1.452 出版当年五年平均 1.41 出版前一年[2017版] 1.785 出版后一年[2019版]

第一作者：

第一作者机构： [1]Department of Medical Oncology, Sichuan Cancer Hospital, Chengdu, Sichuan 610041

通讯作者：

通讯机构： [3]Surgical Center, Sichuan Cancer Hospital, Chengdu, Sichuan 610041, P.R. China [*1]Surgical Center, Sichuan Cancer Hospital, 55, Section 4, South Ren min Road, Chengdu, Sichuan 610041, P.R. China

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