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LncRNA GHET1 predicts poor prognosis in hepatocellular carcinoma and promotes cell proliferation by silencing KLF2

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收录情况： ◇ SCIE

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机构： [1]Department of Oncology, Sichuan Cancer Hospital and Institute. No.55, the forth section of South Renmin Road, Wuhou District, Chengdu, Sichuan, China [2]Cancer Center, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China [3]Cancer Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China [4]Ministry of Science and Technology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China

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关键词： GHET1 hepatocellular carcinoma KLF2 long non-coding RNA proliferation

摘要：

Hepatocellular carcinoma (HCC) has been identified as one of the leading causes of cancer-related death worldwide. Recently, long non-coding RNAs (lncRNAs) attract much attention of researchers, and they are demonstrated to be dysregulated in a variety of cancers, including HCC. LncRNA gastric carcinoma high expressed transcript 1 lncRNA GHET1 is found to be dysregulated in gastric cancer (GC). However, its clinical value and potential biological function in HCC remains unclear. In this study, the expression level of GHET1 was analyzed in 72 HCC tissues and matched normal tissues by using Quantitative RT-PCR (qRT-PCR). GHET1 expression was significantly up-regulated in HCC tissues and the higher level of GHET1 was related to vascular invasion, cirrhosis, tumor size, edmindson grade, and poor prognosis. Moreover, knockdown of GHET1 inhibited cell proliferation of HCC, and also caused cell cycle arrest and induced apoptosis in HCC cell lines. We also found that GHET1 could epigenetically repress transcription of Kruppel-like factor 2 (KLF2) in HCC cells by recruiting PRC2 into KLF2 promoter region. Our results indicated that lncRNA GHET1, as a growth regulator, might serve as a novel prognostic biomarker and therapy target for HCC.

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出版当年[2018]版：

大类 | 2 区生物

小类 | 2 区生理学 3 区细胞生物学

最新[2023]版：

大类 | 2 区生物学

小类 | 2 区生理学 3 区细胞生物学

JCR分区：

出版当年[2018]版：

Q1 PHYSIOLOGY Q2 CELL BIOLOGY

最新[2023]版：

Q1 PHYSIOLOGY Q2 CELL BIOLOGY

影响因子： 4.5 最新[2023版] 5.3 最新五年平均 4.522 出版当年[2018版] 4.085 出版当年五年平均 3.923 出版前一年[2017版] 5.546 出版后一年[2019版]

第一作者：

第一作者机构： [1]Department of Oncology, Sichuan Cancer Hospital and Institute. No.55, the forth section of South Renmin Road, Wuhou District, Chengdu, Sichuan, China

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通讯作者：

通讯机构： [2]Cancer Center, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China [3]Cancer Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China [*1]Cancer Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 611731, Sichuan, China

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