机构：[1]Health Management Center, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital,Chengdu, Sichuan 610072四川省人民医院[2]School of Medicine, University of Electronic Science and Technology of China, Chengdu,Sichuan 610054四川省人民医院[3]Key Laboratory for Genetics of Human Disease, Sichuan Academy of Medical Science and SichuanProvincial People's Hospital, Chengdu, Sichuan 610072四川省人民医院[4]Department of Clinical Pharmacy, Sichuan Cancer Hospitaland Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China,Chengdu, Sichuan 610054临床药学部临床药学部四川省人民医院四川省肿瘤医院[5]Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy,Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China四川省人民医院
Necroptosis is a type of programmed cell death with necrotic morphology, occurring in a variety of biological processes, including inflammation, immune response, embryonic development and metabolic abnormalities. The current nomenclature defines necroptosis as cell death mediated by signal transduction from receptor-interacting serine/threonine kinase (RIP) 1 to RIP3 (hereafter called RIP1/RIP3). However, RIP3-dependent cell death would be a more precise definition of necroptosis. RIP3 is indispensable for necroptosis, while RIP1 is not consistently involved in the signal transduction. Notably, deletion of RIP1 even promotes RIP3-mediated necroptosis under certain conditions. Necroptosis was previously thought as an alternate process of cell death in case of apoptosis inhibition. Currently, necroptosis is recognized to serve a pivotal role in regulating various physiological processes. Of note, it mediates a variety of human diseases, such as ischemic brain injury, immune system disorders and cancer. Targeting and inhibiting necroptosis, therefore, has the potential to be used for therapeutic purposes. To date, research has elucidated the suppression of RIP1/RIP3 via effective inhibitors and highlighted their potential application in disease therapy. The present review focused on the molecular mechanisms of RIP1/RIP3-mediated necroptosis, explored the functions of RIP1/RIP3 in necroptosis, discussed their potential as a novel therapeutic target for disease therapy, and provided valuable suggestions for further study in this field.
基金：
National Science Foundation
of China (grant no 81802504), the Sichuan National Science
Research Funding (grant no. 2018JY0645), Sichuan Health and
Family Planning Commission Funding (grant no. 16ZD0253),
Chengdu National Science Research Funding (grant
no. 2018‑YFYF‑00146‑SN), and funding from the Sichuan
Scientific Research Grant for Returned Overseas Chinese
Scholars for Dr Yi Wang. This study was also supported by the
National Key Research and Development Plan of China (grant
no. 2017YFC0113901), the Key Research and Development
Plan of Sichuan Science and Technology Bureau (grant
no. 2019YFS0278), the Health Care for government officials of
Sichuan Province and the Sichuan Health and Family Planning
Commission Funding (grant no. 120094) for Dr Yuping Liu.
第一作者机构：[1]Health Management Center, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital,Chengdu, Sichuan 610072
共同第一作者：
通讯作者：
通讯机构：[1]Health Management Center, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital,Chengdu, Sichuan 610072[5]Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy,Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China[*1]Health Management Center, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, 32 West Ring Road, Chengdu, Sichuan 610072, P.R. China[*2]Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, 32 West Ring Road, Chengdu, Sichuan 610072, P.R. China
推荐引用方式(GB/T 7714)：
Liu Yuping,Liu Ting,Lei Tiantian,et al.RIP1/RIP3-regulated necroptosis as a target for multifaceted disease therapy (Review)[J].INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE.2019,44(3):771-786.doi:10.3892/ijmm.2019.4244.
APA：
Liu, Yuping,Liu, Ting,Lei, Tiantian,Zhang, Dingding,Du, Suya...&Wang, Yi.(2019).RIP1/RIP3-regulated necroptosis as a target for multifaceted disease therapy (Review).INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,44,(3)
MLA：
Liu, Yuping,et al."RIP1/RIP3-regulated necroptosis as a target for multifaceted disease therapy (Review)".INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 44..3(2019):771-786
