四川省科技厅重点研发项目(19ZD YF0291)%四川省卫生计生委重点项目(18SYJS07)%四川省学术技术带头人培养基金(编号:川人社办发(2015) 100)%成都市优秀人才培养计划项目 This study was supported by grants from Science and Technology Department of Sichuan Province(19ZDYF0291)%Health and Family Planning Commission of Sichuan Province(18SYJS07)%by Sichuan Provincial Academic and Technical Leaders Training Fund [ Human Resources and Social Se-curity Bureau, NO. (2015) 100] and Chengdu Talent Training Program