The prognostic value of interim PET or PET/CT performed after 1-4 cycles of chemotherapy has been widely confirmed in Hodgkin lymphoma and diffuse large B-cell lymphoma but remains unknown in T-cell and natural killer (T/NK) cell lymphomas. Therefore, our aim was to investigate the prognostic value of interim and posttherapy PET/CT in T/NK-cell lymphomas. Methods: A retrospective analysis was conducted on data from 88 patients with newly diagnosed T/NK-cell lymphoma who underwent interim (after 1-4 cycles of chemotherapy, n = 62) or posttherapy PET/CT (after the completion of first-line therapy, n = 47). Interim and posttherapy PET/CT status (positive vs. negative) was visually interpreted according to criteria of the International Harmonization Project, and PET/CT status was assessed for its ability to predict progression-free survival (PFS) and overall survival (OS). Results: Interim PET/CT results were negative in 17 of 62 (27.4%) cases, and posttherapy PET/CT results were negative in 29 of 47 (61.7%) cases. The 2-y PFS and OS rates were 71.9% and 80.2%, respectively, in patients with negative results at interim PET/CT versus 20.5% and 46.9%, respectively, in patients with positive results (P < 0.001 and P = 0.022, respectively). The 2-y PFS and OS rates were 57.8% and 78.0%, respectively, in patients with negative results on posttherapy PET/CT versus 0% and 20.4%, respectively, in patients with positive results (P < 0.001 and P = 0.003, respectively). Bivariate analysis showed that interim PET/CT status and posttherapy PET/CT status remain independent predictors of PFS and OS after controlling for the score on the Prognostic Index for Peripheral T-Cell Lymphoma, Unspecified. Conclusion: Both interim PET/CT status and posttherapy PET/CT status are independent predictors of PFS and OS in T/NK-cell lymphomas.
基金：
National Natural Scientific Research Fund of China [30400589, 81071950]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [10ykpy36]; Key Projects in the National Science and Technology Pillar Program during the Eleventh Five-Year Plan Period of China [2008ZX09312-002, 2012ZX09301]; National University Outstanding Young Teacher Support Program at Sun Yat-Sen University; Research Award Fund for Outstanding Young Researchers at Sun Yat-Sen University Cancer Center
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外文
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出版当年[2013]版：
大类|1 区医学
小类|1 区核医学
最新[2023]版：
大类|1 区医学
小类|2 区核医学
第一作者：
第一作者机构：[1]State Key Lab Oncol South China, Guangzhou, Guangdong, Peoples R China[2]Sun Yat Sen Univ, Ctr Canc, Dept Med Oncol, Guangzhou 510060, Guangdong, Peoples R China
通讯作者：
通讯机构：[1]State Key Lab Oncol South China, Guangzhou, Guangdong, Peoples R China[2]Sun Yat Sen Univ, Ctr Canc, Dept Med Oncol, Guangzhou 510060, Guangdong, Peoples R China
推荐引用方式(GB/T 7714)：
Li Ya-Jun,Li Zhi-Ming,Xia Xi-Ya,et al.Prognostic Value of Interim and Posttherapy F-18-FDG PET/CT in Patients with Mature T-Cell and Natural Killer Cell Lymphomas[J].JOURNAL OF NUCLEAR MEDICINE.2013,54(4):507-515.doi:10.2967/jnumed.112.110262.
APA：
Li, Ya-Jun,Li, Zhi-Ming,Xia, Xi-Ya,Huang, Hui-Qiang,Xia, Zhong-Jun...&Jiang, Wen-Qi.(2013).Prognostic Value of Interim and Posttherapy F-18-FDG PET/CT in Patients with Mature T-Cell and Natural Killer Cell Lymphomas.JOURNAL OF NUCLEAR MEDICINE,54,(4)
MLA：
Li, Ya-Jun,et al."Prognostic Value of Interim and Posttherapy F-18-FDG PET/CT in Patients with Mature T-Cell and Natural Killer Cell Lymphomas".JOURNAL OF NUCLEAR MEDICINE 54..4(2013):507-515
医学