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Impact of tils on the prognosis of IIIB colon cancer associated with c-FLIP

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机构： [1]Biotherapy Center, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China

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关键词： C-FLIP L Colon cancer Prognosis Tumor-infiltrating lymphocytes

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Background: To find out useful tools to evaluate the prognosis of colon cancer, this study investigated how c-FLIP L and tumor-infiltrating lymphocytes (TILs) are correlated with the prognosis of patients with stage IIIB colon cancer. Methods: 180 cases of pathologically proven specimens with stage IIIB colon cancer (T3N1M0, AJCC, 7 th edition) were collected at Sun Yat-sen University Cancer Center. The expression of c-FLIP L and the density of TILs in tumor tissues were examined through immunohistochemical analysis. The correlation of c-FLIP L and TILs, with the prognosis of patients was analyzed. Results: C-FLIP L was correlated with an unfavorable overall survival (OS). The densities of CD8+ and CD45RO+ T cells were associated with a favorable OS, whereas Foxp3+ Treg cells were related to an unfavorable OS. However, the relationship between TILs and prognosis varied for two groups of patients that were divided according to c-FLIP L expression. In the group with high c-FLIP L expression, a high density of CD8+ and CD45RO+ T cells or a low density of Foxp3+ Treg cells was correlated with a short OS; In the group with low c-FLIP L expression, a high density of CD8+ and CD45RO+ T cells or a low density of Foxp3+ Treg cells was correlated with a long OS. Conclusion: This study revealed that the relationship between the density of TILs and the prognosis of colon cancer depended on the expression of c-FLIP L , indicating that the clinical outcome of immune response depended on not only the subtypes of TILs but also the genetic background of cancer cells. © 2017, E-Century Publishing Corporation. All rights reserved.

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大类 | 4 区医学

小类 | 4 区医学：研究与实验

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第一作者机构： [1]Biotherapy Center, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China

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