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High PD-L1 Expression Is Closely Associated With Tumor-Infiltrating Lymphocytes and Leads to Good Clinical Outcomes in Chinese Triple Negative Breast Cancer Patients

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机构： [1]Breast Disease Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China [2]Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China [3]Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China [4]Department of Breast and Thyroid Surgery, The Seventh Affiliated Hospital, Sun Yat-sen University, ShenZhen, 518107, China

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关键词： PD-L1 TIL breast cancer TNBC prognosis

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Background: To investigate the role of Programmed death ligand 1 (PD-L1) expression and tumor-infiltrating lymphocytes (TILs) in tumor recurrence and metastasis of Chinese patients suffering from triple negative breast cancer (TNBC). Methods: PD-L1 immunohistochemistry was performed on 215 TNBCs. Also, the prevalence of TILs correlated the expression of PD-L1 and TILs with clinical outcomes. Kaplan-Meier and the model analyses of univariate Cox proportional hazards were utilized to compare the survival of patients with positive PD-L1 expression with those with negative PD-L1 expression. Results: The median follow-up time was 67.7 months (range: 7-159 months). PD-L1-positive breast cancer patients had significantly longer disease-free survival (DFS) and Overall survival (OS) compared with PD-L1-negative patients (P=0.046; P=0.019) in TNBC. The presence of increased stromal lymphocytic infiltrates (STILs) was significantly associated with overall survival (P=0.026). The model analysis of univariate Cox proportional hazards showed that PD-L1 and STILs were independent prognostic factors for tumor prognosis. Conclusions: Our study found that high levels of PD-L1 could be expressed in TNBC, which was correlated with the prevalence of TILs.

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出版当年[2017]版：

大类 | 2 区生物

小类 | 3 区生化与分子生物学

最新[2023]版：

大类 | 2 区

生物学

小类 | 2 区生化与分子生物学

第一作者：

第一作者机构： [1]Breast Disease Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China [4]Department of Breast and Thyroid Surgery, The Seventh Affiliated Hospital, Sun Yat-sen University, ShenZhen, 518107, China

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通讯机构： [1]Breast Disease Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China

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