Cytoplasmic polyadenylation element-binding protein 4 (CPEB4), a zinc-finger-containing sequence-specific RNA-binding protein, has been associated with tumor proliferation, invasion, and migration. Expression of CPEB4 and its prognostic significance in human colorectal cancer (CRC) have not been studied. The aim of the present study was to investigate expression of CPEB4 and its prognostic significance in CRC. Expression of CPEB4 in CRC tissues from two independent cohorts was examined by immunohistochemistry. Prognostic significance was analyzed using receiver operating characteristic curve analysis, Kaplan-Meier curves, and Cox regression analysis. High expression of CPEB4 was observed in 14.8 % of CRCs in the training cohort and 12.2 % of CRCs in the validation cohort. High expression of CPEB4 was significantly correlated with the pM classification, TNM stage, and poorer overall survival in both cohorts. Through multivariate Cox regression analysis, high expression of CPEB4 was found to be an independent prognostic biomarker for overall survival in CRC patients. High expression of CPEB4 may be an independent and useful biomarker for predicting the poor survival of patients with CRC.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81,400,604, 81,402,412]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区医学
小类|3 区病理学
最新[2023]版：
大类|3 区医学
小类|2 区病理学
第一作者：
第一作者机构：[1]Sun Yat Sen Univ, Affiliated Hosp 6, Dept Colorectal Surg, 26 Yuancun Er Heng Rd, Guangzhou 510655, Guangdong, Peoples R China;[2]Sun Yat Sen Univ, Affiliated Hosp 6, Guangdong Prov Key Lab Colorectal & Pelv Floor Di, 26 Yuancun Er Heng Rd, Guangzhou 510655, Guangdong, Peoples R China;
通讯作者：
通讯机构：[1]Sun Yat Sen Univ, Affiliated Hosp 6, Dept Colorectal Surg, 26 Yuancun Er Heng Rd, Guangzhou 510655, Guangdong, Peoples R China;[2]Sun Yat Sen Univ, Affiliated Hosp 6, Guangdong Prov Key Lab Colorectal & Pelv Floor Di, 26 Yuancun Er Heng Rd, Guangzhou 510655, Guangdong, Peoples R China;
推荐引用方式(GB/T 7714)：
He Xiaosheng,Lin Xutao,Cai Muyan,et al.High expression of cytoplasmic polyadenylation element-binding protein 4 correlates with poor prognosis of patients with colorectal cancer[J].VIRCHOWS ARCHIV.2017,470(1):37-45.doi:10.1007/s00428-016-2037-3.
APA：
He, Xiaosheng,Lin, Xutao,Cai, Muyan,Fan, Dejun,Chen, Xiuting...&Wang, Jianping.(2017).High expression of cytoplasmic polyadenylation element-binding protein 4 correlates with poor prognosis of patients with colorectal cancer.VIRCHOWS ARCHIV,470,(1)
MLA：
He, Xiaosheng,et al."High expression of cytoplasmic polyadenylation element-binding protein 4 correlates with poor prognosis of patients with colorectal cancer".VIRCHOWS ARCHIV 470..1(2017):37-45
