The Xeroderma pigmentosum group G (XPG) gene promotes recognition and excision of damaged DNA during the DNA repair process. We conducted a comprehensive search of the MEDLINE, EMBASE, and Chinese Biomedical databases for publications evaluating the association XPG gene rs751402 C>T polymorphism and overall cancer risk. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were adopted to assess the strength of the association. A total of 22 publications encompassing 10538 cases and 10511 control subjects were included in the final meta-analysis. We found the polymorphism to be associated with increased cancer risk (TT vs. CC: OR = 1.18, 95% CI = 1.01-1.38, P = 0.040; CT vs. CC: OR = 1.12, 95% CI = 1.01-1.24, P = 0.040; and CT/TT vs. CC: OR = 1.12, 95% CI = 1.002-1.26, P = 0.045). Stratification by cancer type indicated that this polymorphism may increase the risk of gastric cancer and hepatocellular carcinoma, which was further confirmed by a false-positive report probability analysis. Genotype-based mRNA expression provides further evidence that this polymorphism is associated with altered XPG mRNA expression. This meta-analysis suggests XPG gene rs751402 C>T polymorphism correlates with overall cancer risk, especially for gastric cancer and hepatocellular carcinoma.
基金：
Scientific Research Foundation of Wenzhou [2015Y0492]; Zhejiang Provincial Medical and Health Science and Technology plan [2009A148]; Zhejiang Provincial Science and Technology Animal Experimental Platform Project [016C37113]; Special Financial Grant; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2014T70836]
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外文
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出版当年[2017]版：
大类|2 区医学
小类|2 区肿瘤学3 区细胞生物学
最新[2023]版：
无
第一作者：
第一作者机构：[1]Wenzhou Med Univ, Affiliated Hosp 2, Dept Hematol, Wenzhou 325027, Zhejiang, Peoples R China;[2]Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Zhejiang, Peoples R China;
通讯作者：
通讯机构：[1]Wenzhou Med Univ, Affiliated Hosp 2, Dept Hematol, Wenzhou 325027, Zhejiang, Peoples R China;[2]Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Zhejiang, Peoples R China;[7]Guangzhou Med Univ, Dept Pediat Surg, Guangzhou Inst Pediat, Guangzhou Women & Childrens Med Ctr, Guangzhou 510623, Guangdong, Peoples R China
推荐引用方式(GB/T 7714)：
Zhou Haixia,Shi Ting-Yan,Zhang Wenwen,et al.XPG gene rs751402 C>T polymorphism and cancer risk: Evidence from 22 publications[J].ONCOTARGET.2017,8(32):53613-53622.doi:10.18632/oncotarget.19421.
APA：
Zhou, Haixia,Shi, Ting-Yan,Zhang, Wenwen,Li, Qiwen,Zhu, Jinhong...&Ruan, Jichen.(2017).XPG gene rs751402 C>T polymorphism and cancer risk: Evidence from 22 publications.ONCOTARGET,8,(32)
MLA：
Zhou, Haixia,et al."XPG gene rs751402 C>T polymorphism and cancer risk: Evidence from 22 publications".ONCOTARGET 8..32(2017):53613-53622
