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Emerging Role of MicroRNAs in mTOR Signaling

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机构： [1]Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Oncol Dept, Sch Med, Shanghai 201999, Peoples R China; [2]Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Guangdong, Peoples R China; [3]Rutgers Robert Wood Johnson Med Sch, 675 Hoes Lane West, Piscataway, NJ 08854 USA; [4]Rutgers State Univ, Rutgers Canc Inst New Jersey, 195 Little Albany St, New Brunswick, NJ 08903 USA

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关键词： mTOR MicroRNA Cancer Cell signaling pathway Biomarker

摘要：

Mechanistic target of rapamycin (mTOR) is a conserved serine/threonine kinase that plays a critical role in the control of cellular growth and metabolism. Hyperactivation of mTOR pathway is common in human cancers, driving uncontrolled proliferation. MicroRNA (miRNA) is a class of short noncoding RNAs that regulate the expression of a wide variety of genes. Deregulation of miRNAs is a hallmark of cancer. Recent studies have revealed interplays between miRNAs and the mTOR pathway during cancer development. Such interactions appear to provide a fine-tuning of various cellular functions and contribute qualitatively to the behavior of cancer. Here we provide an overview of current knowledge regarding the reciprocal relationship between miRNAs and mTOR pathway: regulation of mTOR signaling by miRNAs and control of miRNA biogenesis by mTOR. Further research in this area may prove important for the diagnosis and therapy of human cancer.

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出版当年[2017]版中科院分区表Review为是的期刊

：

大类 | 2 区生物

小类 | 2 区生化与分子生物学 3 区细胞生物学

最新[2023]版：

大类 | 2 区

生物学

小类 | 2 区生化与分子生物学 2 区细胞生物学

第一作者：

第一作者机构： [1]Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Oncol Dept, Sch Med, Shanghai 201999, Peoples R China;

通讯作者：

通讯机构： [1]Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Oncol Dept, Sch Med, Shanghai 201999, Peoples R China; [2]Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Guangdong, Peoples R China; [3]Rutgers Robert Wood Johnson Med Sch, 675 Hoes Lane West, Piscataway, NJ 08854 USA; [4]Rutgers State Univ, Rutgers Canc Inst New Jersey, 195 Little Albany St, New Brunswick, NJ 08903 USA

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