Serum low-density lipoprotein and low-density lipoprotein expression level at diagnosis are favorable prognostic factors in patients with small-cell lung cancer (SCLC)
Background: Patients with small-cell lung cancer (SCLC) patients demonstrate varied survival outcomes. Previous studies have reported that lipoproteins are associated with prognosis in various cancers; however, the role of low-density lipoprotein (LDL) and low-density lipoprotein-cholesterol (LDLR) in patients with SCLC has not been studied. Methods: In this study, the impact of LDL and LDLR on the prognosis of SCLC patients was evaluated. A total of 601 patients with SCLC were retrospectively evaluated, in which 198 patients had adequate tissues for immunohistochemistry, and serum LDL and LDLR expression levels at baseline were tested. X-tile tool, and univariate and multivariate Cox analysis were used to assess the association between LDL, LDLR and overall survival (OS). Results: Univariate analysis demonstrated that a lower LDL level was significantly associated with superior OS (P = 0.037). Similarly, LDLR also significantly predicted OS (P = 0.003). Multivariate Cox analyses confirmed that lower LDL and LDLR expression was independent prognostic factors associated with longer OS (P = 0.019 and P = 0.027, respectively). Conclusions: This study showed that both LDL and LDLR are prognostic indexes for survival in patients with SCLC. Patients with high LDL or LDLR expression level may benefit from treatment that modulates lipoprotein combined with platinum-based chemotherapy.
基金：
Wu Jieping Medical Foundation Project [08-JC-003]; Innovative drug R&D center based on real-time high-throughput cell-based screening platform and large capacity compound library [2013ZX09401003-002]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81,372,502, 81,602,011]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区医学
小类|3 区肿瘤学
最新[2023]版：
大类|2 区医学
小类|3 区肿瘤学
第一作者：
第一作者机构：[1]Sun Yat Sen Univ, Dept Med Oncol, Canc Ctr, 651 Dongfeng East Rd, Guangzhou 510060, Guangdong, Peoples R China;[2]State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China;[3]Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Guangdong, Peoples R China;
通讯作者：
通讯机构：[1]Sun Yat Sen Univ, Dept Med Oncol, Canc Ctr, 651 Dongfeng East Rd, Guangzhou 510060, Guangdong, Peoples R China;[2]State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China;[3]Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Guangdong, Peoples R China;
推荐引用方式(GB/T 7714)：
Zhou Ting,Zhan Jianhua,Fang Wenfeng,et al.Serum low-density lipoprotein and low-density lipoprotein expression level at diagnosis are favorable prognostic factors in patients with small-cell lung cancer (SCLC)[J].BMC CANCER.2017,17(1):-.doi:10.1186/s12885-017-3239-z.
APA：
Zhou, Ting,Zhan, Jianhua,Fang, Wenfeng,Zhao, Yuanyuan,Yang, Yunpeng...&Zhang, Li.(2017).Serum low-density lipoprotein and low-density lipoprotein expression level at diagnosis are favorable prognostic factors in patients with small-cell lung cancer (SCLC).BMC CANCER,17,(1)
MLA：
Zhou, Ting,et al."Serum low-density lipoprotein and low-density lipoprotein expression level at diagnosis are favorable prognostic factors in patients with small-cell lung cancer (SCLC)".BMC CANCER 17..1(2017):-
医学