Disulfiram (DS), an anti-alcoholism drug, shows very strong cytotoxicity in many cancer types. However its clinical application in cancer treatment is limited by the very short half-life in the bloodstream. In this study, we developed a poly lactic-co-glycolic acid (PLGA)encapsulated DS protecting DS from the degradation in the bloodstream. The newly developed DS-PLGA was characterized. The DS-PLGA has very satisfactory encapsulation efficiency, drug-loading content and controlled release rate in vitro. PLGA encapsulation extended the half-life of DS from shorter than 2 minutes to 7 hours in serum. In combination with copper, DS-PLGA significantly inhibited the liver cancer stem cell population. CI-isobologram showed a remarkable synergistic cytotoxicity between DS-PLGA and 5-FU or sorafenib. It also demonstrated very promising anticancer efficacy and antimetastatic effect in liver cancer mouse model. Both DS and PLGA are FDA approved products for clinical application. Our study may lead to repositioning of DS into liver cancer treatment. (C) 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
基金：
Marie-Curie IIF ProgramEuropean Union (EU) [PIIF-GA-2013-629478]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|1 区工程技术
小类|2 区医学：研究与实验3 区纳米科技
最新[2023]版：
大类|2 区医学
小类|3 区医学：研究与实验3 区纳米科技
第一作者：
第一作者机构：[1]Wolverhampton Univ, Fac Sci & Engn, Wolverhampton, W Midlands, England;
通讯作者：
通讯机构：[1]Wolverhampton Univ, Fac Sci & Engn, Wolverhampton, W Midlands, England;[2]Third Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing, Peoples R China;[3]Third Mil Med Univ, Southwest Hosp, Southwest Canc Ctr, Chongqing, Peoples R China;[11]Minist Educ China, Key Lab Tumor Immunopathol, Chongqing, Peoples R China;[12]Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, Guangzhou, Guangdong, Peoples R China
推荐引用方式(GB/T 7714)：
Wang Zhipeng,Tan Jiao,McConville Christopher,et al.Poly lactic-co-glycolic acid controlled delivery of disulfiram to target liver cancer stem-like cells[J].NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE.2017,13(2):641-657.doi:10.1016/j.nano.2016.08.001.
APA：
Wang, Zhipeng,Tan, Jiao,McConville, Christopher,Kannappan, Vinodh,Tawari, Patricia Erebi...&Wang, Weiguang.(2017).Poly lactic-co-glycolic acid controlled delivery of disulfiram to target liver cancer stem-like cells.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,13,(2)
MLA：
Wang, Zhipeng,et al."Poly lactic-co-glycolic acid controlled delivery of disulfiram to target liver cancer stem-like cells".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 13..2(2017):641-657
工程技术