Circulatory microRNA 23a and microRNA 23b and polycystic ovary syndrome (PCOS): the effects of body mass index and sex hormones in an Eastern Han Chinese population.
机构：[1]Department of Integrative Medicine and Neurobiology, State Key Lab of Medical Neurobiology, School of Basic Medical Sciences, Shanghai Medical College, Institute of Acupuncture Research (WHO collaborating center for traditional medicine) and Institute of Brain Science, Brain Science Collaborative Innovation Center, Fudan University, Shanghai 200032, China.[2]Grade 2008 Clinical Medicine, Shanghai Medicine School, Fudan University, Shanghai 200032, China.[3]Department of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.[4]Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.[5]Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.[6]Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China.[7]Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg 40530, Sweden.
MicroRNAs (miRNAs) regulate the expression of genes involved in various cellular functions related to metabolism, inflammation, and reproduction. This study evaluated the effects of sex hormones and obesity on the expression of circulating miR-23a and miR-23b in women with polycystic ovary syndrome (PCOS) and healthy women.
Serum sex hormones concentrations and body mass index (BMI) were measured in 18 women with PCOS and in 30 healthy women from the East China area and these measurements were correlated with serum miR-23a/b levels. The effect of miR-23a and miR-23b risk factors on occurrence of PCOS and predisposing factors of PCOS on these miRNA expressions were evaluated.
The expressions of miR-23a/b were significantly lower in the women with PCOS than the normal women, and the expression levels of miR-23a/b were positively correlated with each other in the normal women (p = 0.001) but not in the women with PCOS (p > 0.05). In the women with PCOS, miR-23a was positively correlated with BMI (p = 0.03). However, no correlations were found between the levels of miR-23a/b and the sex hormones in the normal and PCOS women. On the other hand, without considering the presence or absence of PCOS, increase in BMI had a positive effect on the levels of circulating miR-23b; while testosterone had negative effects on the levels of circulating miR-23a. Furthermore, the likelihood of women with PCOS decreased by 0.01-fold for every 1 fold increase of miR-23a expression.
Both reduced levels and discordance between the expressions of miR-23a/b were observed in the women with PCOS and miR-23a/b were affected from testosterone and BMI, reversely. Therefore, miR-23a alteration in contrast with miR-23b is a better indicator for evaluation of PCOS than the miR-23b.
基金：
Zhengyi Fund of Shanghai Medical School, Fudan University; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [J1210041, 81673766, 81572555]; Swedish Medical Research CouncilSwedish Medical Research Council (SMRC); Goteborgs Lakaresallskap; Tore Nilson Foundation; Swedish federal government under the LUA/ALF [5859, ALFGBG-147791]; Chinese Special Fund [2014T70392]; New Teacher Priming Fund; Zuoxue Foundation of Fudan University; Development Project of Shanghai Peak Disciplines-Integrated Chinese and Western Medicine; Fredrik and Ingrid Thurings Foundation
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区生物
小类|3 区生殖生物学
最新[2023]版：
大类|3 区医学
小类|3 区生殖生物学
第一作者：
第一作者机构：[1]Department of Integrative Medicine and Neurobiology, State Key Lab of Medical Neurobiology, School of Basic Medical Sciences, Shanghai Medical College, Institute of Acupuncture Research (WHO collaborating center for traditional medicine) and Institute of Brain Science, Brain Science Collaborative Innovation Center, Fudan University, Shanghai 200032, China.[2]Grade 2008 Clinical Medicine, Shanghai Medicine School, Fudan University, Shanghai 200032, China.[3]Department of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Integrative Medicine and Neurobiology, State Key Lab of Medical Neurobiology, School of Basic Medical Sciences, Shanghai Medical College, Institute of Acupuncture Research (WHO collaborating center for traditional medicine) and Institute of Brain Science, Brain Science Collaborative Innovation Center, Fudan University, Shanghai 200032, China.[6]Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China.
推荐引用方式(GB/T 7714)：
Weixi Xiong,Ying Lin,Lili Xu,et al.Circulatory microRNA 23a and microRNA 23b and polycystic ovary syndrome (PCOS): the effects of body mass index and sex hormones in an Eastern Han Chinese population.[J].Journal of ovarian research.2017,10(1):10.doi:10.1186/s13048-016-0298-8.
APA：
Weixi Xiong,Ying Lin,Lili Xu,Amin Tamadon,Shien Zou...&Yi Feng.(2017).Circulatory microRNA 23a and microRNA 23b and polycystic ovary syndrome (PCOS): the effects of body mass index and sex hormones in an Eastern Han Chinese population..Journal of ovarian research,10,(1)
MLA：
Weixi Xiong,et al."Circulatory microRNA 23a and microRNA 23b and polycystic ovary syndrome (PCOS): the effects of body mass index and sex hormones in an Eastern Han Chinese population.".Journal of ovarian research 10..1(2017):10
