机构：[1]Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu, China[2]Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, China[3]Department of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre, West China Hospital, Sichuan University, Chengdu, China[4]National Institute for Health Research (NIHR) Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, University of Liverpool, Liverpool, UK
There are currently 2 Tumour-Node-Metastasis (TNM) staging systems for pancreatic neuroendocrine tumours (p-NETs) - European Neuroendocrine Tumour Society (ENETS) and American Joint Committee on Cancer (AJCC). P-NETs being heterogeneous, we investigated the prognostic value of the 2 systems in p-NETs, as a whole, and more interestingly in functional and non-functional sub-groups separately, with a view to ascertaining any potential clinical benefits of using one system over the other.
Data from patients with surgically resected p-NETs were retrospectively reviewed. Kaplan-Meier method and Cox Regression proportional hazards model were used to analyse overall survival (OS) and prognostic predictors respectively.
In the whole group of 165 patients, both TNM systems successfully discriminated OS differences when comparing stages I and II with stages III and IV (P<0.05); ENETS stage III patients had a significantly better OS than those in stage IV (P=0.003). Patients with functional p-NETs in ENETS stage II showed a statistically better OS than those in stages III and IV (P<0.05). For non-functional tumours, the AJCC staging system could effectively discriminate between the OS differences of patients in stage I with stages III and IV, or stage II with III and IV (P<0.05). Along with surgical intent and World Health Organisation (WHO) 2010 grade, both ENETS and AJCC staging systems were effective predictors of OS for different function-status p-NETs.
The ENETS system might have potential advantages when applied to all p-NETs and to the functional sub-group, while the AJCC system might be clinically more practical for non-functional p-NETs.
基金：
Application Infrastructure Projects of Sichuan Province [2014YJ0180]; NIHR Biomedical Research Unit Funding Scheme (UK)
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|2 区医学
小类|2 区肿瘤学3 区细胞生物学
最新[2023]版：
无
第一作者：
第一作者机构：[1]Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu, China
共同第一作者：
通讯作者：
通讯机构：[2]Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, China
推荐引用方式(GB/T 7714)：
Yang Min,Ke Neng-Wen,Zhang Yi,et al.Functional and non-functional pancreatic neuroendocrine tumours: ENETS or AJCC TNM staging system?[J].Oncotarget.2017,8(47):82784-82795.doi:10.18632/oncotarget.20007.
APA：
Yang Min,Ke Neng-Wen,Zhang Yi,Tan Chun-Lu,Tian Bo-Le...&Sutton Robert.(2017).Functional and non-functional pancreatic neuroendocrine tumours: ENETS or AJCC TNM staging system?.Oncotarget,8,(47)
MLA：
Yang Min,et al."Functional and non-functional pancreatic neuroendocrine tumours: ENETS or AJCC TNM staging system?".Oncotarget 8..47(2017):82784-82795
