机构：[1]Department of Forensic Biology, West China School of Basic sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041, P.R. China[2]Department of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, P.R. China[3]Department of Forensic Medicine, Nanjing Medical University, Nanjing, Jiangsu, 211166, P.R. China[4]Laboratory of Molecular Translational Medicine, West China Institute of Women & Children’s Health, Key Laboratory of Obstetric & Gynecologic & Pediatric Diseases & Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, P.R. China[5]Department of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, P.R. China
The purpose of the present study is to investigate the association between the polymorphisms in AXIN1 with susceptibility to clear cell renal cell carcinoma (ccRCC).
A total of 284 ccRCC patients and 439 healthy volunteers were enrolled. Totally three tag single nucleotide polymorphisms in AXIN1 gene were genotyped using PCR & restriction fragment length polymorphism.
Significantly increased ccRCC risk was observed to be associated with the CT/CC genotypes of rs1805105 and AA genotype of rs12921862. Patients carrying the rs1805105 CT genotype had a 1.92-fold increased risk to developing clinical stage III and IV cancer.
Our results suggested the rs1805105 CT/CC genotypes and rs12921862 AA genotype may relate to ccRCC development.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81172440, 81172494, 81272821, 81202023]; Applied Basic Research Programs of Science and Technology Commission Foundation of Sichuan ProvinceScience & Technology Commission of Shanghai Municipality (STCSM) [2012SZ0008]; Science Foundation for The Excellent Youth Scholars of Sichuan University [2011SCU04A16]
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区医学
小类|4 区医学：研究与实验
最新[2023]版：
大类|4 区医学
小类|4 区医学：研究与实验
第一作者：
第一作者机构：[1]Department of Forensic Biology, West China School of Basic sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041, P.R. China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Forensic Biology, West China School of Basic sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041, P.R. China[4]Laboratory of Molecular Translational Medicine, West China Institute of Women & Children’s Health, Key Laboratory of Obstetric & Gynecologic & Pediatric Diseases & Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, P.R. China
推荐引用方式(GB/T 7714)：
Pu Yan,Mi Xuhua,Chen Peng,et al.Genetic association of polymorphisms in AXIN1 gene with clear cell renal cell carcinoma in a Chinese population.[J].Biomarkers in medicine.2017,11(11):947-955.doi:10.2217/bmm-2016-0377.
APA：
Pu Yan,Mi Xuhua,Chen Peng,Zhou Bin,Zhang Peng...&Zhang Lin.(2017).Genetic association of polymorphisms in AXIN1 gene with clear cell renal cell carcinoma in a Chinese population..Biomarkers in medicine,11,(11)
MLA：
Pu Yan,et al."Genetic association of polymorphisms in AXIN1 gene with clear cell renal cell carcinoma in a Chinese population.".Biomarkers in medicine 11..11(2017):947-955
