机构：[1]Tumor Treatment Center, Renmin Hospital of Wuhan University, Hubei,[2]Department of Radiotherapy, The First Affiliated Hospital of Guangxi Medical University, Guangxi,[3]State Key Laboratory of Oncology in South China and Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China.其他部门华南肿瘤学国家重点实验室中山大学肿瘤防治中心
Background: Numerous studies have focused on the association of methionine synthase (MS) A2756G polymorphism and acute hematological cancer risk. However, the results remain inconsistent. Therefore, a meta-analysis was performed to derive a more precise estimate of the association between them. Methods: This meta-analysis involved 25 articles (26 studies) including 8641 hematological cancer patients and 15,498 controls. The pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) of the association between MS A2756G polymorphism and the risk of hematological cancer were calculated. Results: Overall, no significant increased risks were found between MS A2756G polymorphism and hematological cancer risk under allelic homozygote (GA vs AA: OR=0.98, 95% CI=0.89-1.07, P=.62), heterozygote (GG vs AA: OR=0.99, 95% CI=0.85-1.15, P=.91), dominant (AG+GG vs AA: OR=0.99, 95% CI=0.90-1.08, P=.93), and recessive (GG vs AG+AA: OR=1.00, 95% CI=0.86-1.16, P=.97) models, respectively. In the stratified analyses by ethnicity and source of controls, there were still no significant associations between them in all genetic models. Conclusions: Therefore, these findings demonstrate that MS A2756G polymorphism may not be a risk factor for hematological cancer.
基金：
Natural Science Foundation of Hubei Province of China [2011CDB489]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区医学
小类|3 区医学：内科
最新[2023]版：
大类|4 区医学
小类|4 区医学：内科
第一作者：
第一作者机构：[1]Tumor Treatment Center, Renmin Hospital of Wuhan University, Hubei,
共同第一作者：
通讯作者：
通讯机构：[3]State Key Laboratory of Oncology in South China and Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China.[*1]State Key Laboratory of Oncology in South China and Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, 651 Dongfeng East Rd, Guangzhou, Guangdong, 510060, People’s Republic of China
推荐引用方式(GB/T 7714)：
Wu Bing,Liu Kang,Yang Jun-Ping,et al.The association between methionine synthase A2756G polymorphism and hematological cancer A meta-analysis[J].MEDICINE.2017,96(48):-.doi:10.1097/MD.0000000000007469.
APA：
Wu, Bing,Liu, Kang,Yang, Jun-Ping,Hu, Yan,Zhang, Jun&He, Jun-xiang.(2017).The association between methionine synthase A2756G polymorphism and hematological cancer A meta-analysis.MEDICINE,96,(48)
MLA：
Wu, Bing,et al."The association between methionine synthase A2756G polymorphism and hematological cancer A meta-analysis".MEDICINE 96..48(2017):-
