机构：[1]Cancer Institute, Collaborative Innovation Center for Cancer Medicine, Fudan University Shanghai Cancer Center, Shanghai, .China[2]Department of Pathology, First Afiliated Hospital, Xinjiang Medical University, Urumqi, China[3]Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China[4]Ministry of Education Key Laboratory of Contemporary Anthropology, State Key Laboratory of Genetic Engineering, Schoolof life Sciences, Fudan University, Shanghai, China[5]Fudan-Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China[6]Department of Hepatobiliary Oncology, State Key Laboratory of Oncology in South China, Sun Yat-Sen University CancerCenter, Guangzhou, China临床科室其他部门肝胆胰科华南肿瘤学国家重点实验室中山大学肿瘤防治中心[7]Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA[8]Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
Genetic variants of nucleotide excision repair (NER) genes have been extensively investigated for their roles in the development of prostate cancer (PCa); however, the published results have been inconsistent. In a hospital-based case-control study of 1,004 PCa cases and 1,055 cancer-free controls, we genotyped eight potentially functional single nucleotide polymorphisms (SNPs) of NER genes (i.e., XPC, rs2228001 T>G and rs1870134 G>C; XPD, rs13181 T>G and rs238406 G>T; XPG, rs1047768 T>C, rs751402 C>T, and rs17655 G>C; and XPF, rs2276464 G>C) and assessed their associations with risk of PCa by using logistic regression analysis. Among these eight SNPs investigated, only XPC rs1870134 CG/CC variant genotypes were associated with a decreased risk of prostate cancer under a dominant genetic model (adjusted odds ratio [OR] = 0.77, 95% confidence interval [CI] = 0.64-1.91, P = 0.003). Phenotype-genotype analysis also suggested that the XPC rs1870134 CG/CC variant genotypes were associated with significantly decreased expression levels of XPC mRNA in a mix population of different ethnicities. These findings suggested that XPC SNPs may contribute to risk of PCa in Eastern Chinese men.
基金：
"China's Thousand Talents Program" Recruitment at Fudan University; Science and Technology Committee of Shanghai Municipality [12DZ2260100]; Ministry of Science and Technology [2011BAI09B00]; Ministry of Health [201002007]; National Natural Science Foundation of China [81460513, 81302101]
语种：
外文
被引次数：
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PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|2 区医学
小类|2 区肿瘤学3 区细胞生物学
最新[2023]版：
无
第一作者：
第一作者机构：[1]Cancer Institute, Collaborative Innovation Center for Cancer Medicine, Fudan University Shanghai Cancer Center, Shanghai, .China[8]Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
共同第一作者：
通讯作者：
通讯机构：[1]Cancer Institute, Collaborative Innovation Center for Cancer Medicine, Fudan University Shanghai Cancer Center, Shanghai, .China[3]Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China[7]Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA[8]Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
推荐引用方式(GB/T 7714)：
Wang Mengyun,Li Qiaoxin,Gu Chengyuan,et al.Polymorphisms in nucleotide excision repair genes and risk of primary prostate cancer in Chinese Han populations[J].ONCOTARGET.2017,8(15):24362-24371.doi:10.18632/oncotarget.13848.
APA：
Wang, Mengyun,Li, Qiaoxin,Gu, Chengyuan,Zhu, Yao,Yang, Yajun...&Wei, Qingyi.(2017).Polymorphisms in nucleotide excision repair genes and risk of primary prostate cancer in Chinese Han populations.ONCOTARGET,8,(15)
MLA：
Wang, Mengyun,et al."Polymorphisms in nucleotide excision repair genes and risk of primary prostate cancer in Chinese Han populations".ONCOTARGET 8..15(2017):24362-24371
