Development and external validation of nomograms to predict the risk of skeletal metastasis at the time of diagnosis and skeletal metastasis-free survival in nasopharyngeal carcinoma
机构：[1]Sun Yat-sen University Cancer Center, 651 East Dong Feng Road, Guangzhou 510060, China.中山大学肿瘤防治中心[2]State Key Laboratory of Oncology in Southern China, Guangzhou, China.其他部门华南肿瘤学国家重点实验室中山大学肿瘤防治中心[3]Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.[4]The Six Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.[5]The First Hospital of Foshan, Foshan, China.[6]The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
Background: The skeletal system is the most common site of distant metastasis in nasopharyngeal carcinoma (NPC); various prognostic factors have been reported for skeletal metastasis, though most studies have focused on a single factor. We aimed to establish nomograms to effectively predict skeletal metastasis at initial diagnosis (SMAD) and skeletal metastasis-free survival (SMFS) in NPC. Methods: A total of 2685 patients with NPC who received bone scintigraphy (BS) and/or 18F-deoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) and 2496 patients without skeletal metastasis were retrospectively assessed to develop individual nomograms for SMAD and SMFS. The models were validated externally using separate cohorts of 1329 and 1231 patients treated at two other institutions. Results: Five independent prognostic factors were included in each nomogram. The SMAD nomogram had a significantly higher c-index than the TNM staging system (training cohort, P = 0.005; validation cohort, P < 0.001). The SMFS nomogram had significantly higher c-index values in the training and validation sets than the TNM staging system (P < 0.001 and P = 0.005, respectively). Three proposed risk stratification groups were created using the nomograms, and enabled significant discrimination of SMFS for each risk group. Conclusion: The prognostic nomograms established in this study enable accurate stratification of distinct risk groups for skeletal metastasis, which may improve counseling and facilitate individualized management of patients with NPC.
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外文
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出版当年[2017]版：
大类|3 区医学
小类|3 区肿瘤学
最新[2023]版：
大类|2 区医学
小类|3 区肿瘤学
第一作者：
第一作者机构：[1]Sun Yat-sen University Cancer Center, 651 East Dong Feng Road, Guangzhou 510060, China.[2]State Key Laboratory of Oncology in Southern China, Guangzhou, China.[3]Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
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通讯作者：
通讯机构：[1]Sun Yat-sen University Cancer Center, 651 East Dong Feng Road, Guangzhou 510060, China.[2]State Key Laboratory of Oncology in Southern China, Guangzhou, China.[3]Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
推荐引用方式(GB/T 7714)：
Yang Lin,Xia Liangping,Wang Yan,et al.Development and external validation of nomograms to predict the risk of skeletal metastasis at the time of diagnosis and skeletal metastasis-free survival in nasopharyngeal carcinoma[J].BMC CANCER.2017,17(1):-.doi:10.1186/s12885-017-3630-9.
APA：
Yang, Lin,Xia, Liangping,Wang, Yan,He, Shasha,Chen, Haiyang...&Chen, Yong.(2017).Development and external validation of nomograms to predict the risk of skeletal metastasis at the time of diagnosis and skeletal metastasis-free survival in nasopharyngeal carcinoma.BMC CANCER,17,(1)
MLA：
Yang, Lin,et al."Development and external validation of nomograms to predict the risk of skeletal metastasis at the time of diagnosis and skeletal metastasis-free survival in nasopharyngeal carcinoma".BMC CANCER 17..1(2017):-
医学