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Ski regulates Smads and TAZ signaling to suppress lung cancer progression

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机构： [1]China State Key Laboratory of Respiratory Disease and Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China [2]State Key Laboratory of Oncology in Southern China, Department of Colorectal Surgery, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China [3]Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China

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关键词： lung cancer ski TAZ TGF- YAP

摘要：

Ski, the transforming protein of the avian Sloan-Kettering retrovirus, displays both pro- and anti-oncogenic activities in human cancer. The mechanisms underlying these conflicting observations have not been fully understood. Herein, we investigated the mechanism underlying the tumor suppressor activity of Ski. To investigate the effect of Ski re-activation on TGF- and Hippo/TAZ pathway, we measured its effect on the endogenous Smad target genes (PAI-1 and P15(INK4B)) and TAZ target gene CTGF. The results revealed that Ski exerted its inhibitory activity in TGF-1/Smad signaling pathway. Ski inhibited TAZ by increasing their phosphorylation by Lats2 and did not alter the localization of TAZ. Ski inhibited lung cancer growth and invasion. Ski methylation correlated with decreased mRNA expression in human lung cancer cell lines. Thus, Ski inhibited the function of TGF- and TAZ through multiple mechanisms in human lung cancer.

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出版当年[2017]版：

大类 | 2 区医学

小类 | 2 区生化与分子生物学 2 区肿瘤学

最新[2023]版：

大类 | 2 区医学

小类 | 2 区生化与分子生物学 3 区肿瘤学

第一作者：

第一作者机构： [1]China State Key Laboratory of Respiratory Disease and Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China [*]China State Key Laboratory of Respiratory Disease and Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

通讯作者：

通讯机构： [1]China State Key Laboratory of Respiratory Disease and Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China [*]China State Key Laboratory of Respiratory Disease and Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

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