机构：[1]China State Key Laboratory of Respiratory Disease and Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China[2]State Key Laboratory of Oncology in Southern China, Department of Colorectal Surgery, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China临床科室其他部门结直肠科华南肿瘤学国家重点实验室中山大学肿瘤防治中心[3]Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China其他科室麻醉科中山大学附属第一医院
Ski, the transforming protein of the avian Sloan-Kettering retrovirus, displays both pro- and anti-oncogenic activities in human cancer. The mechanisms underlying these conflicting observations have not been fully understood. Herein, we investigated the mechanism underlying the tumor suppressor activity of Ski. To investigate the effect of Ski re-activation on TGF- and Hippo/TAZ pathway, we measured its effect on the endogenous Smad target genes (PAI-1 and P15(INK4B)) and TAZ target gene CTGF. The results revealed that Ski exerted its inhibitory activity in TGF-1/Smad signaling pathway. Ski inhibited TAZ by increasing their phosphorylation by Lats2 and did not alter the localization of TAZ. Ski inhibited lung cancer growth and invasion. Ski methylation correlated with decreased mRNA expression in human lung cancer cell lines. Thus, Ski inhibited the function of TGF- and TAZ through multiple mechanisms in human lung cancer.
基金：
Natural Science Foundation of Guangdong Province [S2013040014688]; National Natural Science Foundation of China [81301999, 81672293]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|2 区医学
小类|2 区生化与分子生物学2 区肿瘤学
最新[2023]版：
大类|2 区医学
小类|2 区生化与分子生物学3 区肿瘤学
第一作者：
第一作者机构：[1]China State Key Laboratory of Respiratory Disease and Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China[*]China State Key Laboratory of Respiratory Disease and Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
通讯作者：
通讯机构：[1]China State Key Laboratory of Respiratory Disease and Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China[*]China State Key Laboratory of Respiratory Disease and Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
推荐引用方式(GB/T 7714)：
Mian Xie,Xiaojun Wu,Jinjun Zhang,et al.Ski regulates Smads and TAZ signaling to suppress lung cancer progression[J].MOLECULAR CARCINOGENESIS.2017,56(10):2178-2189.doi:10.1002/mc.22661.
APA：
Mian Xie,Xiaojun Wu,Jinjun Zhang,Jiexia Zhang&Xiangxiang Li.(2017).Ski regulates Smads and TAZ signaling to suppress lung cancer progression.MOLECULAR CARCINOGENESIS,56,(10)
MLA：
Mian Xie,et al."Ski regulates Smads and TAZ signaling to suppress lung cancer progression".MOLECULAR CARCINOGENESIS 56..10(2017):2178-2189
