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Periodontitis Induces Arterial Microbiota Shifts and Immune Dysregulation Contributing to Peripheral Vascular Inflammation

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资源类型：
Pubmed体系：
作者：
Zhu Xuanzhi[1,2] * ; Cheng Shouzheng[1,2] ; Ge Jinting[3] ; Weng Chengxin[3] ; Fang Kun[4] ; Chen Jiali[1,5] ; Yang Renjie[1,6] ; Shi Bing[1,5] ; Shao Dan[1] ; Zhao Lei[1,2] ; Leong Kam W[7,8] ; Wu Yafei[1,2] ; Huang Hanyao[1,5,7] ;
机构： [1]State Key Laboratory of Oral Diseases &National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China. [2]Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China. [3]Division of Vascular Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [4]Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, New York, USA. [5]Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China. [6]Eastern Clinic, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China. [7]Department of Biomedical Engineering, Columbia University, New York, New York, USA. [8]Department of Systems Biology, Columbia University Medical Center, New York, New York, USA.
出处：
DOI： 10.1111/jcpe.70055
ISSN：

关键词： 2bRAD-M endothelial cell fatty acid binding protein 4 periodontitis peripheral arterial disease scRNA-seq

摘要：
To explore periodontitis-induced changes in the femoral artery microbiota and their impact on the immune system, seeking to clarify the mechanisms underlying the link between periodontitis and peripheral arterial diseases (PADs).A ligature-induced periodontitis mouse model was used. 2bRAD sequencing for microbiome (2bRAD-M) was applied to analyse the femoral artery microbiota, and single-cell RNA sequencing (scRNA-seq) was used to characterise the arterial immune microenvironment.Periodontitis significantly altered the femoral artery microbiota. There was increase in the relative abundance of anaerobic bacteria and reduction in aerobic and facultative anaerobic bacteria. Lipopolysaccharide (LPS) concentrations in both blood and the femoral artery were elevated. scRNA-seq showed an increase in fatty acid binding protein 4 (FABP4+) endothelial cells (ECs). FABP4+ ECs were more responsive to LPS, which promoted neutrophil infiltration and T-cell differentiation.These findings identify FABP4+ ECs as key mediators in the connection between periodontitis and PADs. The study provides new insights into the systemic effects of periodontitis and offers a basis for developing preventive and therapeutic strategies for periodontitis-associated vascular diseases.© 2025 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

基金：
This work was supported by the National Natural Science Foundation of China, 82301148, 82170970, 81970944; China Postdoctoral ScienceFoundation, 2024T170605; Sichuan Province Science and Technology Support Program, 2025ZNSFSC0758; Sichuan Postdoctoral Science Foundation, TB2022005;Health Commission of Sichuan Province Medical Science and Technology Program, 24QNMP060; Research Funding from West China School/Hospital ofStomatology Sichuan University, RCDWJS2024-7; Cross-disciplinary Innovation Project, West China School of Stomatology, Sichuan University, RD-03-202105
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类 | 1 区 医学
小类 | 1 区 牙科与口腔外科
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 牙科与口腔外科
第一作者：
第一作者机构： [1]State Key Laboratory of Oral Diseases &National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China. [2]Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
通讯作者：
通讯机构： [1]State Key Laboratory of Oral Diseases &National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China. [2]Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China. [5]Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China. [7]Department of Biomedical Engineering, Columbia University, New York, New York, USA. [8]Department of Systems Biology, Columbia University Medical Center, New York, New York, USA.
推荐引用方式(GB/T 7714)：
Zhu Xuanzhi,Cheng Shouzheng,Ge Jinting,et al.Periodontitis Induces Arterial Microbiota Shifts and Immune Dysregulation Contributing to Peripheral Vascular Inflammation[J].Journal Of Clinical Periodontology.2025,doi:10.1111/jcpe.70055.
APA：
Zhu Xuanzhi,Cheng Shouzheng,Ge Jinting,Weng Chengxin,Fang Kun...&Huang Hanyao.(2025).Periodontitis Induces Arterial Microbiota Shifts and Immune Dysregulation Contributing to Peripheral Vascular Inflammation.Journal Of Clinical Periodontology,,
MLA：
Zhu Xuanzhi,et al."Periodontitis Induces Arterial Microbiota Shifts and Immune Dysregulation Contributing to Peripheral Vascular Inflammation".Journal Of Clinical Periodontology .(2025)

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