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Decreased blood vessel density and endothelial cell subset dynamics during ageing of the endocrine system.

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机构: [1]Tissue and Tumor Microenvironments Group, The Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK [2]Department of Prosthodontics, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China [3]The Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK [4]Structural Genomics Consortium, NDM, University of Oxford, Oxford, UK [5]Institute of Clinical Sciences, Imperial College London, London, UK [6]MRC London Institute of Medical Sciences, Imperial College London, London, UK
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关键词: 3D imaging ageing endocrine system pancreas vasculature

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Age-associated alterations of the hormone-secreting endocrine system cause organ dysfunction and disease states. However, the cell biology of endocrine tissue ageing remains poorly understood. Here, we perform comparative 3D imaging to understand age-related perturbations of the endothelial cell (EC) compartment in endocrine glands. Datasets of a wide range of markers highlight a decline in capillary and artery numbers, but not of perivascular cells in pancreas, testis and thyroid gland, with age in mice and humans. Further, angiogenesis and β-cell expansion in the pancreas are coupled by a distinct age-dependent subset of ECs. While this EC subpopulation supports pancreatic β cells, it declines during ageing concomitant with increased expression of the gap junction protein Gja1. EC-specific ablation of Gja1 restores β-cell expansion in the aged pancreas. These results provide a proof of concept for understanding age-related vascular changes and imply that therapeutic targeting of blood vessels may restore aged endocrine tissue function. This comprehensive data atlas offers over > 1,000 multicolour volumes for exploration and research in endocrinology, ageing, matrix and vascular biology. © 2020 The Authors. Published under the terms of the CC BY 4.0 license.

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出版当年[2021]版:
大类 | 1 区 生物学
小类 | 1 区 生化与分子生物学 1 区 细胞生物学
最新[2023]版:
大类 | 1 区 生物学
小类 | 1 区 生化与分子生物学 1 区 细胞生物学
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第一作者机构: [1]Tissue and Tumor Microenvironments Group, The Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK [2]Department of Prosthodontics, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
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