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Advances in nanomaterials for enhancing cGAS-STING pathway mediated anti-tumor treatment

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Wu Ruicheng[1,2,3] * ; Wang Jie[2] * ; Li Dengxiong[1,2] * ; Li Ao[4] * ; Yoo Koo Han[5] ; Liu Zhihong[2] ; Wei Wuran[2] ; Wang Zhipeng[6] ; Feng Dechao[1,2,3] ;
机构： [1]Department of Urology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang Province, China [2]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, 610041, China [3]Division of Surgery & Interventional Science, University College London, London, W1W 7TS, UK [4]Department of Pediatric Urology, Sichuan University West China Second University Hospital, Chengdu, Sichuan, China [5]Department of Urology, Kyung Hee University, South Korea [6]Department of Urology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China
出处：
DOI： 10.1016/j.mtbio.2025.102190

关键词： cGAS-STING pathway Nanomaterials Cancer immunotherapy Targeted delivery

摘要：
The cGAS-STING pathway is a crucial component of innate immunity, playing a dual role in tumor biology by promoting pro-inflammatory responses and anti-tumor immunity. Nanomaterials have emerged as transformative tools to enhance the activation and therapeutic efficacy of this pathway in cancer immunotherapy. This review targets recent advancements in nanomaterials of enhancing cGAS-STING-mediated anti-tumor immune responses. These nanomaterials leverage their unique physical and chemical properties for targeted delivery, controlled release, and biodegradability, significantly improving the anti-tumor effects through synergistic activation of the cGAS-STING pathway. This review underscores the potential of nanomaterial-based cGAS-STING therapeutics for cancer treatment and identifies key research priorities to address existing limitations and propel the field forward.© 2025 The Authors. Published by Elsevier Ltd.

语种：
外文
被引次数：
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类 | 1 区 医学
小类 | 1 区 材料科学：生物材料 2 区 工程：生物医学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 材料科学：生物材料 2 区 工程：生物医学
JCR分区：
出版当年[2024]版：
Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS
最新[2024]版：
Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS

影响因子： 最新[2024版] 最新五年平均 出版当年[2024版] 出版当年五年平均 出版前一年[2024版]

第一作者：
第一作者机构： [1]Department of Urology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang Province, China [2]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, 610041, China [3]Division of Surgery & Interventional Science, University College London, London, W1W 7TS, UK
共同第一作者：
通讯作者：
通讯机构： [1]Department of Urology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang Province, China [2]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, 610041, China [3]Division of Surgery & Interventional Science, University College London, London, W1W 7TS, UK
推荐引用方式(GB/T 7714)：
Wu Ruicheng,Wang Jie,Li Dengxiong,et al.Advances in nanomaterials for enhancing cGAS-STING pathway mediated anti-tumor treatment[J].Materials Today. Bio.2025,34:102190.doi:10.1016/j.mtbio.2025.102190.
APA：
Wu Ruicheng,Wang Jie,Li Dengxiong,Li Ao,Yoo Koo Han...&Feng Dechao.(2025).Advances in nanomaterials for enhancing cGAS-STING pathway mediated anti-tumor treatment.Materials Today. Bio,34,
MLA：
Wu Ruicheng,et al."Advances in nanomaterials for enhancing cGAS-STING pathway mediated anti-tumor treatment".Materials Today. Bio 34.(2025):102190

相关文献

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