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Unveiling the research advances of sepsis: pathogenesis, precise intervention and clinical perspective

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机构： [1]Emergency Department, Zigong Fourth People's Hospital, Sichuan, China. [2]State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Sichuan, China. [3]Innovation Center of Nursing Research, Nursing Key Laboratory of Sichuan Province, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Sichuan, China. [4]Institute of Medical Big Data, Zigong Academy of Artificial Intelligence and Big Data for Medical Science,Sichuan, China.

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关键词： sepsis pathogenesis Gram-negative bacteria sepsis subtype precision treatment

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Sepsis is a life-threatening multi-organ dysfunction caused by the dysregulated systemic inflammatory and immune responses in the host to an infection. Despite continuous advances in the treatment of sepsis, its high morbidity and mortality seriously challenge global public health. Symptomatic treatments are currently applied to sepsis patients, while precise treatments acting on the individualized etiological and pathogenic factors are scant. To address the issue, the present review aims to illustrate the pathogenic mechanisms of Gram-negative bacteria, the immune imbalance of co-existing continuous inflammation and immunosuppression, and the increased susceptibility resulting from the imbalanced gut microbiota. Moreover, we summarized the therapeutic strategies for sepsis and the development of precise treatment acting on sepsis patients' individualized subphenotypes and immune statuses. From the perspectives of etiological factors, pathogenesis, and precision treatment, we provide new insights into the future treatment of sepsis.Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.

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大类 | 2 区医学

小类 | 2 区外科

最新[2025]版：

大类 | 2 区医学

小类 | 2 区外科

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第一作者机构： [1]Emergency Department, Zigong Fourth People's Hospital, Sichuan, China.

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通讯机构： [1]Emergency Department, Zigong Fourth People's Hospital, Sichuan, China. [3]Innovation Center of Nursing Research, Nursing Key Laboratory of Sichuan Province, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Sichuan, China. [4]Institute of Medical Big Data, Zigong Academy of Artificial Intelligence and Big Data for Medical Science,Sichuan, China.

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