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Unraveling metastatic timing: insights and challenges from genomic evolution

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机构： [1]Colorectal Cancer Center, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, PR China [2]Institute of Digestive Surgery, Institute of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, PR China. [3]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, PR China. [4]Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China.

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关键词： cancer metastasis Metastasis timing Genomic evolution Phylogenetic analysis

摘要：

Metastasis, a significant hurdle in cancer treatment, is driven by genetic alterations that shape tumor evolution and dissemination. Traditionally viewed as a late-stage event, recent evidence suggests that metastasis may initiate earlier in tumor progression than previously assumed. Genomic studies have been instrumental in exploring this complex process, yet inconsistencies persist, with findings supporting both early and late metastatic events. These discrepancies are likely due to methodological variations in how metastasis timing is inferred. Additionally, biases in sampling and the heterogeneity of metastatic seeding further obscure precise assessments of metastatic divergence. Addressing these challenges is essential to refining evolutionary models of metastasis, which will be crucial for advancing cancer research and improving therapeutic strategies. In this review, we examine the challenges in accurately timing metastatic events and discuss how insights into early versus late dissemination can inform personalized therapeutic strategies. Such perspectives can lead to more personalized and effective cancer management.Copyright © 2025 Elsevier B.V. All rights reserved.

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出版当年[2025]版中科院分区表Review为是的期刊

：

大类 | 2 区

医学

小类 | 2 区生化与分子生物学 2 区生物物理 2 区肿瘤学

最新[2025]版

：

大类 | 2 区

医学

小类 | 2 区生化与分子生物学 2 区生物物理 2 区肿瘤学

第一作者：

第一作者机构： [1]Colorectal Cancer Center, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, PR China [2]Institute of Digestive Surgery, Institute of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, PR China.

通讯作者：

通讯机构： [1]Colorectal Cancer Center, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, PR China [2]Institute of Digestive Surgery, Institute of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, PR China. [3]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, PR China. [4]Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China.

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