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Hypoxia-driven angiogenesis and metabolic reprogramming in vascular tumors

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机构： [1]Department of Pediatric Pulmonology and Immunology, West China Second University Hospital, Sichuan University, Chengdu, China, [2]Key Laboratory of Birth Defect and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China, [3]NHC Key Laboratory of Chronobiology (Sichuan University), Chengdu, China, [4]The Joint Laboratory for Lung Development and Related Diseases of West China Second University Hospital, Sichuan University and School of Life Sciences of Fudan University, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu, China, [5]Sichuan Birth Defects Clinical Research Center, West China Second University Hospital, Sichuan University, Chengdu, China, [6]Department of Radiotherapy, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, National Clinical Research Center for Geriatrics, Sichuan University, Chengdu, China, [7]Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China, [8]Department of Pediatric Pulmonology and Immunology, WCSUH-Tianfu·Sichuan Provincial Children’s Hospital, Sichuan University, Meishan, China

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关键词： vascular tumors hypoxia HIF-1α angiogenesis metabolic reprogramming tumor microenvironment

摘要：

Hypoxia is a hallmark of the tumor microenvironment (TME), and it plays a crucial role in the occurrence and progression in vascular tumors. Under hypoxic conditions, hypoxia-inducible factor 1-alpha (HIF-1α) is stabilized, inducing changes in the expression of various target genes involved in angiogenesis, metabolism, and cell survival. This includes the upregulation of pro-angiogenic factors like VEGF, which promotes the formation of dysfunctional blood vessels, contributing to the worsening of the hypoxic microenvironment. At the same time, hypoxia induces a metabolic shift toward glycolysis, even in the presence of oxygen, supporting tumor cell survival and proliferation by providing necessary energy and biosynthetic precursors. This review discusses the molecular mechanisms by which hypoxia regulates angiogenesis and metabolic reprogramming in vascular tumors, highlighting the intricate link between these processes, and explores potential therapeutic strategies to target these pathways in order to develop effective treatment strategies for patients.Copyright © 2025 Liu, Yu, Liu, Xie, Hu and Liu.

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大类 | 2 区生物学

小类 | 2 区发育生物学 3 区细胞生物学

最新[2025]版：

大类 | 2 区生物学

小类 | 2 区发育生物学 3 区细胞生物学

第一作者：

第一作者机构： [1]Department of Pediatric Pulmonology and Immunology, West China Second University Hospital, Sichuan University, Chengdu, China, [2]Key Laboratory of Birth Defect and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China, [3]NHC Key Laboratory of Chronobiology (Sichuan University), Chengdu, China, [4]The Joint Laboratory for Lung Development and Related Diseases of West China Second University Hospital, Sichuan University and School of Life Sciences of Fudan University, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu, China, [5]Sichuan Birth Defects Clinical Research Center, West China Second University Hospital, Sichuan University, Chengdu, China,

通讯作者：

通讯机构： [1]Department of Pediatric Pulmonology and Immunology, West China Second University Hospital, Sichuan University, Chengdu, China, [2]Key Laboratory of Birth Defect and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China, [3]NHC Key Laboratory of Chronobiology (Sichuan University), Chengdu, China, [4]The Joint Laboratory for Lung Development and Related Diseases of West China Second University Hospital, Sichuan University and School of Life Sciences of Fudan University, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu, China, [5]Sichuan Birth Defects Clinical Research Center, West China Second University Hospital, Sichuan University, Chengdu, China, [7]Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China, [8]Department of Pediatric Pulmonology and Immunology, WCSUH-Tianfu·Sichuan Provincial Children’s Hospital, Sichuan University, Meishan, China

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Hypoxia-driven angiogenesis and metabolic reprogramming in vascular tumors

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