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Sarcomatoid squamous cell carcinoma of the cervix: A case series and literature review

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机构: [1]Department of Pathology, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China [2]Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China [3]Department of Emergency, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China [4]Department of pathology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, Sichuan, People's Republic of China
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关键词: Sarcomatoid squamous cell carcinoma Cervix HPV infection Clinicopathological features

摘要:
Primary cervical sarcomatoid squamous cell carcinoma (SSCC), a rare biphasic malignancy with 29 documented cases, is characterized by co-existing malignant squamous epithelium and sarcomatoid spindle cells. Immunohistochemical co-expression of epithelial (PCK) and mesenchymal (vimentin) markers remains diagnostic. We analyzed 8 institutional cases (2006-2024) alongside literature reports. Patients (median age 46, range 28-72) predominantly presented with vaginal bleeding (7/8 cases), while one exhibited abdominal pain with discharge. HPV16 was detected in 2 cases. All tumors showed variable immunoreactivity for PCK, vimentin, p16, and ≥ 1 squamous marker (p63/p40/CK5/6). Treatment included chemotherapy (6/8) and radiotherapy (3/8). Follow-up (median 57.4 months, n = 7) revealed aggressive behavior: two stage IIIC patients developed supraclavicular/visceral metastases (alive with disease at 10-31 months), one stage IIIA patient died at 24 months, while others remained disease-free. Combined analysis with 29 published cases confirms SSCC's dual histologic presentation (biphasic/monophasic) and consistent epithelial-mesenchymal marker co-expression. These findings underscore SSCC's clinicopathologic heterogeneity and metastatic potential despite multimodal therapy.Copyright © 2025. Published by Elsevier Inc.

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大类 | 4 区 医学
小类 | 4 区 病理学
最新[2025]版:
大类 | 4 区 医学
小类 | 4 区 病理学
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Q3 PATHOLOGY
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Q3 PATHOLOGY

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第一作者机构: [1]Department of Pathology, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China [2]Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China
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通讯机构: [1]Department of Pathology, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China [2]Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China
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