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Tumor-infiltrating immune cells state-implications for various breast cancer subtypes

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机构: [1]Department of Immunology, Mudanjiang Medical University, Mudanjiang, Heilongjiang, China. [2]Sunnybrook Research Institute and the Department of Laboratory Medicine and Pathobiology at the University of Toronto, Toronto, ON, Canada. [3]Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan. [4]School of Stomatology and School of Basic Medical Sciences, Mudanjiang Medical University, Mudanjiang, Heilongjiang, China. [5]Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
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关键词: immune cell(s) infiltration molecular subtypes tumor microenvironment (TME) breast cancer clinical significance

摘要:
Breast cancer presents a variety of subtypes due to its cellular and molecular heterogeneity. The capacity of cancer cells to proliferate, invade, and metastasize depends not only on their intrinsic characters but also on their dynamic interaction with the host tumor microenvironment (TME), which includes immune cells. Meanwhile, the infiltration of immune cells in the TME severely affects the occurrence, development, treatment, and prognosis of breast cancer. Therefore, this review aims to explore the immune invasive tumor microenvironment in different intrinsic subtypes of breast cancer. Additionally, it highlights the mechanistic influence of the infiltrating immune cells on stage-wise dynamics of breast tumorigenesis. Moreover, the present review also attempts to discern the regulatory relationship between tumor infiltrating immune cells and immune microenvironment in different molecular subtypes of breast cancer, thus, spotlighting its clinical significance.Copyright © 2025 Xu, Zhang, Yang, Qadir, Yuan and Ye.

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大类 | 2 区 医学
小类 | 2 区 免疫学
最新[2025]版:
大类 | 2 区 医学
小类 | 2 区 免疫学
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第一作者机构: [1]Department of Immunology, Mudanjiang Medical University, Mudanjiang, Heilongjiang, China.
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