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Deciphering the role of IL-17D, its newly identified receptor CD93, and IL-17D-CD93 axis in health and disease

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资源类型：
Pubmed体系：
作者：
Jiang Kexin[1,2,3] * ; Xu Yanjiani[2,3,4] * ; Wang Yan[1,2,3] ; Yin Nanhao[5] ; Huang Fangyang[1,2,3] ; Chen Mao[1,2,3] ;
机构： [1]Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China. [2]Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu, China. [3]Cardiac Structure and Function Research Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, China. [4]West China School of Medicine, Sichuan University, Chengdu, China. [5]Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
出处：
DOI： 10.1093/jimmun/vkaf061
ISSN：

关键词： CD93 interleukin-17D oxidative stress

摘要：
This review explores interleukin (IL)-17D and its receptor CD93, highlighting their structural, functional, and clinical aspects. Identifying CD93 as the receptor for IL-17D has advanced understanding of the IL-17 family and its signaling pathways. IL-17D, with its unique glycoprotein structure, plays diverse roles in oxidative stress response and potential antitumor therapies. It is involved in autoimmune diseases, infections, and cancers, making it a promising therapeutic target. CD93 is crucial in various biological processes, from angiogenesis to inflammatory diseases. CD93's implications in cancers, neuroinflammation, and metabolism highlight its significance as a potential prognostic marker and therapeutic target. The review emphasizes IL-17D and CD93 as promising areas for future research, offering insights into their signaling pathways and potential applications in personalized medicine. Deciphering the relationship between IL-17D and CD93 is in its infancy and invites exploration for transformative advancements in immunology and beyond.© The Author(s) 2025. Published by Oxford University Press on behalf of The American Association of Immunologists. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.

基金：
This research was supported by the National Natural Science Foundation of China (grant numbers: U23A20395, 81900258, and 82170375), the Sichuan Science and Technology Program (grant numbers: 2023YFS0296 and 2022ZDZX0020), Key Research and Development Support Project of Science and Technology Department of Chengdu (2021-YF08-00121-GX); Chinese Medical Association Cardiovascular Branch (CSC) Clinical Research Special Fund Project (CSCF2020B04); West China Hospital “1.3.5 project for disciplines of excellence from West China Hospital of Sichuan University (ZYGD23021, 23HXFH009).”
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类 | 3 区 医学
小类 | 3 区 免疫学
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 免疫学
第一作者：
第一作者机构： [1]Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China. [2]Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu, China. [3]Cardiac Structure and Function Research Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China. [2]Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu, China. [3]Cardiac Structure and Function Research Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, China.
推荐引用方式(GB/T 7714)：
Jiang Kexin,Xu Yanjiani,Wang Yan,et al.Deciphering the role of IL-17D, its newly identified receptor CD93, and IL-17D-CD93 axis in health and disease[J].Journal Of Immunology (Baltimore, Md. : 1950).2025,doi:10.1093/jimmun/vkaf061.
APA：
Jiang Kexin,Xu Yanjiani,Wang Yan,Yin Nanhao,Huang Fangyang&Chen Mao.(2025).Deciphering the role of IL-17D, its newly identified receptor CD93, and IL-17D-CD93 axis in health and disease.Journal Of Immunology (Baltimore, Md. : 1950),,
MLA：
Jiang Kexin,et al."Deciphering the role of IL-17D, its newly identified receptor CD93, and IL-17D-CD93 axis in health and disease".Journal Of Immunology (Baltimore, Md. : 1950) .(2025)

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