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Comparison of 18F-FDG and 68Ga-DOTA-IBA in detecting bone metastases: a lesion-basis study

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机构: [1]Department of Nuclear Medicine, Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, The Affiliated Hospital of Southwest Medical University, No 25 TaiPing St, Jiangyang District, Luzhou, 646000, Sichuan, China. [2]Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, 646000, Sichuan, China. [3]Institute of Nuclear Medicine, Southwest Medical University, Luzhou, 646000, Sichuan, China. [4]Department of Ultrasound, The Affiliated Hospital of Southwest Medical University, No 25 TaiPing St, Jiangyang District, Luzhou, 646000, Sichuan, China.
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关键词: 18F-FDG 68Ga-DOTA-IBA Positron emission tomography (PET) Bone metastasis

摘要:
Gallium 68 (68Ga)-labeled DOTA-conjugate ibandronic acid (DOTA-IBA) has been successfully synthesized and utilized for bone metastasis imaging. This study compares the diagnostic efficacy between 68Ga-DOTA-IBA and fluorine 18 (18F)-labeled fluorodeoxyglucose (FDG) in detecting bone metastases. This prospective study, conducted from October 2022 to September 2023, analyzed images from participants who underwent 68Ga-DOTA-IBA PET/CT and 18F-FDG PET/CT scans. Lesions were classified into five groups based on anatomical location (limbs, vertebrae, pelvis, ribs, and skull). Morphological bone changes were categorized as osteolytic, osteoblastic, or mixed. The semi-quantified radiotracer uptake, measured by the maximum standardized uptake value (SUVmax), was compared using a paired t-test. Detection rates between the two scans were analyzed using the McNemar test. A total of 46 participants (median age: 64 years [interquartile range: 53-68 years], 28 men) were evaluated. 68Ga-DOTA-IBA demonstrated higher diagnostic efficacy than 18F-FDG in detecting bone metastases in the limbs (73.2% vs. 64.1%), vertebras (78.1% vs. 67.4%), ribs (86.6% vs. 62.2%), pelvis (78.6% vs. 68.9%), and skulls (80.0% vs. 38%). For osteoblastic lesions, the detection rate for 68Ga-DOTA-IBA and 18F-FDG was 83.3% and 51.5% respectively (P < 0.001). The SUVmax of 68Ga-DOTA-IBA was 7.88 (95% CI 7.09-8.66), which was higher than that of 18F-FDG at 3.96 (95% CI 3.57-4.35) (P < 0.001). In participants with prostate cancer, the detection rate of 68Ga-DOTA-IBA and 18F-FDG was 84.7% and 55.0% respectively (P < 0.001). The SUVmax of 68Ga-DOTA-IBA was 10.44 (95% CI 8.57-12.30), which was higher than that of 18F-FDG 4.29 (95% CI 3.51-5.07) (P < 0.001). 68Ga-DOTA-IBA PET/CT demonstrates superior diagnostic performance over 18F-FDG PET/CT in detecting bone metastases, particularly in osteoblastic lesions and prostate cancer cases.© 2025. The Author(s).

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出版当年[2025]版:
大类 | 3 区 综合性期刊
小类 | 3 区 综合性期刊
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大类 | 3 区 综合性期刊
小类 | 3 区 综合性期刊
第一作者:
第一作者机构: [1]Department of Nuclear Medicine, Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, The Affiliated Hospital of Southwest Medical University, No 25 TaiPing St, Jiangyang District, Luzhou, 646000, Sichuan, China. [2]Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, 646000, Sichuan, China. [3]Institute of Nuclear Medicine, Southwest Medical University, Luzhou, 646000, Sichuan, China.
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通讯作者:
通讯机构: [1]Department of Nuclear Medicine, Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, The Affiliated Hospital of Southwest Medical University, No 25 TaiPing St, Jiangyang District, Luzhou, 646000, Sichuan, China. [2]Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, 646000, Sichuan, China. [3]Institute of Nuclear Medicine, Southwest Medical University, Luzhou, 646000, Sichuan, China.
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