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The Dynamic Role of Ferroptosis in Cancer Immunoediting: Implications for Immunotherapy

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机构： [1]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646600, China [2]Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, Sichuan 646000, China [3]South Sichuan Institute of Translational Medicine, Luzhou, Sichuan 646600, China [4]School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China [5]Department of Oncology, Luzhou People’s Hospital, Luzhou, Sichuan 646000, China

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关键词： Cancer immunoediting Dual role Ferroptosis Pathways Immunotherapy

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Currently, cancer immunotherapy strategies are primarily formulated based on the patient's present condition, representing a "static" treatment approach. However, cancer progression is inherently "dynamic," as the immune environment is not fixed but undergoes continuous changes. This dynamism is characterized by the ongoing interactions between tumor cells and immune cells, which ultimately lead to alterations in the tumor immune microenvironment. This process can be effectively elucidated by the concept of cancer immunoediting, which divides tumor development into three phases: "elimination," "equilibrium," and "escape." Consequently, adjusting immunotherapy regimens based on these distinct phases may enhance patient survival and improve prognosis. Targeting ferroptosis is an emerging area in cancer immunotherapy, and our findings reveal that the antioxidant systems associated with ferroptosis possess dual roles, functioning differently across the three phases of cancer immunoediting. Therefore, this review delve into the dual role of the ferroptosis antioxidant system in tumor development and progression. It also propose immunotherapy strategies targeting ferroptosis at different stages, ultimately aiming to illuminate the significant implications of targeting ferroptosis at various phases for cancer immunotherapy.Copyright © 2025. Published by Elsevier Ltd.

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大类 | 2 区

医学

小类 | 1 区药学

第一作者：

第一作者机构： [1]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646600, China [2]Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, Sichuan 646000, China [3]South Sichuan Institute of Translational Medicine, Luzhou, Sichuan 646600, China

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通讯机构： [1]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646600, China [2]Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, Sichuan 646000, China [3]South Sichuan Institute of Translational Medicine, Luzhou, Sichuan 646600, China

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