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Ferroptosis-related signaling pathways in cancer drug resistance

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机构： [1]Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China. [2]XiangYa School of Medicine, Central South University, Changsha 410013, Hunan, China. [3]Department of Urology, Innovation Institute for Integration of Medicine and Engineering, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China. [4]First Clinical Department of Changsha Medical University, Changsha 410219, Hunan, China. [5]National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.

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关键词： Ferroptosis drug resistance cancer

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Ferroptosis is an iron-dependent form of programmed cell death induced by lipid peroxidation. This process is regulated by signaling pathways associated with redox balance, iron metabolism, and lipid metabolism. Cancer cells' increased iron demand makes them especially susceptible to ferroptosis, significantly influencing cancer development, therapeutic response, and metastasis. Recent findings indicate that cancer cells can evade ferroptosis by downregulating key signaling pathways related to this process, contributing to drug resistance. This underscores the possibility of modulating ferroptosis as an approach to counteract drug resistance and enhance therapeutic efficacy. This review outlines the signaling pathways involved in ferroptosis and their interactions with cancer-related signaling pathways. We also highlight the current understanding of ferroptosis in cancer drug resistance, offering insights into how targeting ferroptosis can provide novel therapeutic approaches for drug-resistant cancers. Finally, we explore the potential of ferroptosis-inducing compounds and examine the challenges and opportunities for drug development in this evolving field.© The Author(s) 2025.

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第一作者机构： [1]Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China. [2]XiangYa School of Medicine, Central South University, Changsha 410013, Hunan, China.

通讯作者：

通讯机构： [1]Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China. [5]National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.

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