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Managing Cancer Drug Resistance from the Perspective of Inflammation

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机构： [1]The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China. [2]Institute of Digestive Disease of Ningbo University, Ningbo 315020, China. [3]West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610064, China. [4]Ningbo First Hospital, Ningbo 315010, China.

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The development of multidrug resistance in cancer chemotherapy is a major obstacle to the effective treatment of human malignant tumors. Several epidemiological studies have demonstrated that inflammation is closely related to cancer and plays a key role in the development of both solid and liquid tumors. Therefore, targeting inflammation and the molecules involved in the inflammatory process may be a good strategy for treating drug-resistant tumors. In this review, we discuss the molecular mechanisms underlying inflammation in regulating anticancer drug resistance by modulating drug action and drug-mediated cell death pathways. Inflammation alters the effectiveness of drugs through modulation of the expression of multidrug efflux transporters (e.g., ABCG2, ABCB1, and ABCC1) and drug-metabolizing enzymes (e.g., CYP1A2 and CYP3A4). In addition, inflammation can protect cancer cells from drug-mediated cell death by regulating DNA damage repair, downstream adaptive response (e.g., apoptosis, autophagy, and oncogenic bypass signaling), and tumor microenvironment. Intriguingly, manipulating inflammation may affect drug resistance through various molecular mechanisms validated by in vitro/in vivo models. In this review, we aim to summarize the underlying molecular mechanisms that inflammation participates in cancer drug resistance and discuss the potential clinical strategies targeting inflammation to overcome drug resistance.Copyright © 2022 Shuaijun Lu et al.

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出版当年[2022]版：

大类 | 3 区医学

小类 | 4 区肿瘤学

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第一作者：

第一作者机构： [1]The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China. [2]Institute of Digestive Disease of Ningbo University, Ningbo 315020, China.

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通讯机构： [1]The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China. [2]Institute of Digestive Disease of Ningbo University, Ningbo 315020, China.

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