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Vinculin: A new target for the diagnosis and treatment of disease

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机构: [1]Department of Vascular Sungery, The fliated Hopritadl of Southwest Medical Universiy, 646000 laushou, China [2]Metabole Vascular Dieease Key Laboratony' of sichuarn Province, The Aflated Hopital of Soudhwest Medical Univesity, 646000, Lushou, China [3]Key Labornatory of Moedical Elecrophysiology, Ministry of Education & Medical Eectrmphysioloical Key Laboratary of Sicuan Province, (Collaborative Innowation Center for Prevention of Cordiovascular Diseses) Iostioute of Coedlovascular Recarch, Southwest Medical Untvensiy, 646000, Lushou, Chima [4]Department of General Surgery, The Afliated Hopial of Southwest Medical Uniesity, 646000, lushou, China [5]Department of Phamacology, School of Phormacy, Southwest Medical Untbersit, 646000 Luzhou, China
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关键词: Vinculin Cardiovascular disease Gastrointestinal disorders Tumor

摘要:
Vinculin, a crucial adhesion plaque protein, plays a significant role in cell morphology and tissue development. Dysregulation of focal adhesion proteins has been linked to numerous diseases, including cardiovascular conditions, gastrointestinal disorders, and cancer. Recent studies increasingly highlight vinculin's involvement in the progression of these diseases; however, a comprehensive review remains lacking. Therefore, an in-depth and timely review is essential to consolidate the latest findings on vinculin's role in disease mechanisms. This study aims to examine how vinculin coordinates a complex network of signaling pathways across various pathological contexts.Copyright © 2025 The Authors. Published by Elsevier Ltd.. All rights reserved.

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出版当年[2025]版
大类 | 3 区 生物学
小类 | 2 区 生物物理 3 区 生化与分子生物学
最新[2025]版
大类 | 3 区 生物学
小类 | 2 区 生物物理 3 区 生化与分子生物学
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第一作者机构: [1]Department of Vascular Sungery, The fliated Hopritadl of Southwest Medical Universiy, 646000 laushou, China
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通讯作者:
通讯机构: [1]Department of Vascular Sungery, The fliated Hopritadl of Southwest Medical Universiy, 646000 laushou, China [2]Metabole Vascular Dieease Key Laboratony' of sichuarn Province, The Aflated Hopital of Soudhwest Medical Univesity, 646000, Lushou, China [3]Key Labornatory of Moedical Elecrophysiology, Ministry of Education & Medical Eectrmphysioloical Key Laboratary of Sicuan Province, (Collaborative Innowation Center for Prevention of Cordiovascular Diseses) Iostioute of Coedlovascular Recarch, Southwest Medical Untvensiy, 646000, Lushou, Chima [4]Department of General Surgery, The Afliated Hopial of Southwest Medical Uniesity, 646000, lushou, China
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