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Protocatechuic aldehyde ameliorates psoriasis-like skin inflammation and represses keratinocyte-derived IL-1α and CXCL9 via inhibiting STAT3 activation

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Pubmed体系：
作者：
Yang Xiaoxuan[1,2,3] * ; Yang Jie[1,2,4] * ; Zhou Qian[1,2,3] ; Kang Liang[1,2,3] ; Li Xiaoya[1,2,3] ; Guo Wanjun[6] ; Li Fulun[6] ; Deng Yu[1,2,5] ;
机构： [1]Engineering Research Center of Sichuan-Tibet Traditional Medicinal Plant, Chengdu University, Chengdu 610106 China [2]Institute of Cancer Biology and Drug Discovery, Chengdu University, Chengdu 610106 China [3]School of Food and Biological Engineering, Chengdu University, Chengdu 610106 China [4]School of Pharmacy, Chengdu University, Chengdu 610106 China [5]School of Basic Medical Sciences, Chengdu University, Chengdu 610106 China [6]Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437 China
出处：
DOI： 10.1016/j.intimp.2025.114037
ISSN：

关键词： Psoriasis Protocatechuic aldehyde Inflammation STAT3 Ttranscription Keratinocyte

摘要：
Psoriasis is a chronic inflammatory skin disease. Consistent activation of Signal Transducer and Activator of Transcription 3 (STAT3) in epidermal keratinocyte transactivates various keratinocyte-derived pro-inflammatory cytokines and elicits spontaneous psoriasis-like skin inflammation. In the current study, we first report that topical application of protocatechuic aldehyde (PA), the bioactive compound from Salvia miltiorrhiza (Danshen), significantly improved psoriasis-like skin symptoms and reduced immune cell infiltration in psoriatic lesions. Further molecular mechanism studies demonstrated that PA inactivated STAT3 and inhibited STAT3-mediated transactivation of interleukin-1α (IL-1α) and C-X-C motif chemokine ligand 9 (CXCL9) in epidermal keratinocyte both in vivo and in vitro. Knockdown of STAT3 attenuated the repression effect on IL-1α and CXCL9 by PA. Our results suggested that PA repressed the transactivation of IL-1α and CXCL9 through inhibiting STAT3 in keratinocyte. PA could be potentially used for psoriasis topical treatment or be as a lead compound for drug development.Copyright © 2025 Elsevier B.V. All rights reserved.

基金：
This study was supported by the National Natural Science Foundation of China (Grant No. 82174202), the Natural Science Foundation of Sichuan Province (Grant No. 2022NSFSC0726), the Innovative Team Projects of Shanghai Municipal Commission of Health (Grant No. 2022CX011), the Sailing Program of Shanghai Rising-Star Program (Grant No. 22YF1449700).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
无
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 免疫学 2 区 药学
第一作者：
第一作者机构： [1]Engineering Research Center of Sichuan-Tibet Traditional Medicinal Plant, Chengdu University, Chengdu 610106 China [2]Institute of Cancer Biology and Drug Discovery, Chengdu University, Chengdu 610106 China [3]School of Food and Biological Engineering, Chengdu University, Chengdu 610106 China
共同第一作者：
通讯作者：
通讯机构： [1]Engineering Research Center of Sichuan-Tibet Traditional Medicinal Plant, Chengdu University, Chengdu 610106 China [2]Institute of Cancer Biology and Drug Discovery, Chengdu University, Chengdu 610106 China [5]School of Basic Medical Sciences, Chengdu University, Chengdu 610106 China
推荐引用方式(GB/T 7714)：
Yang Xiaoxuan,Yang Jie,Zhou Qian,et al.Protocatechuic aldehyde ameliorates psoriasis-like skin inflammation and represses keratinocyte-derived IL-1α and CXCL9 via inhibiting STAT3 activation[J].International Immunopharmacology.2025,147:114037.doi:10.1016/j.intimp.2025.114037.
APA：
Yang Xiaoxuan,Yang Jie,Zhou Qian,Kang Liang,Li Xiaoya...&Deng Yu.(2025).Protocatechuic aldehyde ameliorates psoriasis-like skin inflammation and represses keratinocyte-derived IL-1α and CXCL9 via inhibiting STAT3 activation.International Immunopharmacology,147,
MLA：
Yang Xiaoxuan,et al."Protocatechuic aldehyde ameliorates psoriasis-like skin inflammation and represses keratinocyte-derived IL-1α and CXCL9 via inhibiting STAT3 activation".International Immunopharmacology 147.(2025):114037

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