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Proteomic Analysis of Plasma Exosomes Enables the Identification of Lung Cancer in Patients With Chronic Obstructive Pulmonary Disease

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资源类型：
Pubmed体系：
作者：
Zhang Huohuo[1,2] * ; Wu Jiaxuan[1,2] * ; Gan Jiadi[1,2] ; Wang Wei[3] ; Liu Yi[1,2] ; Song Tingting[2,4,5] ; Yang Yongfeng[2,4,5] ; Ji Guiyi[3] ; Li Weimin[1,2,4,5,6,7] ;
机构： [1]Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [2]Institute of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [3]Health Management Center, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [4]Precision Medicine Center, Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [5]Institute of Respiratory Health, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [6]The Research Units of West China, Chinese Academy of Medical Sciences, West China Hospital, Chengdu, Sichuan, China. [7]State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Chengdu, Sichuan, China.
出处：
DOI： 10.1111/1759-7714.15517
ISSN：

关键词： COPD exosome label-free quantification (LFQ) lung cancer parallel reaction monitoring (PRM) plasma proteomics

摘要：
Chronic obstructive pulmonary disease (COPD) is confirmed as an independent risk factor for the development of lung cancer. Although low-dose CT screening significantly reduces the mortality rate of lung cancer, the misdiagnosis and missed diagnosis rates remain high in the COPD population. Additionally, several COPD patients are unable to undergo invasive histological examinations. Therefore, there is an urgent need for minimally invasive biomarkers to screen or diagnose lung cancer in COPD patients. In this study, peripheral blood samples were collected from COPD patients with and without lung cancer. Plasma exosomes (EVs) were extracted for proteomic analysis. Sixteen differentially expressed proteins (DEPs) were preliminarily selected via label-free quantification (LFQ) proteomic technology and comprehensive bioinformatics analysis. Parallel reaction monitoring (PRM) targeted validation identified five candidate proteins associated with COPD with lung cancer. Compared to the COPD group, KRT1, KRT9, and KRT10 were significantly upregulated in the COPD with lung cancer group, while GPLD1 and TF were downregulated. The biomarkers identified in our study provide a foundation for non-invasive screening and diagnosis of lung cancer in COPD patients and exploration of the mechanisms shared between COPD and lung cancer.© 2025 The Author(s). Thoracic Cancer published by John Wiley & Sons Australia, Ltd.

基金：
This work is supported by Natural Science Foundation of Sichuan Province (No.2023NSFSC1458), National Natural Science Foundation of China (Nos. 92159302 to W Li), the Science and Technology Project of Sichuan (2022ZDZX0018 to W Li), and 1.3.5 project for disciplines of excellence and West China Hospital, Sichuan University (ZYGD22009 to W Li). The authors are greatly grateful to PTM Biolab Inc. (Hangzhou, China) for mass spectrometry analysis.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
无
最新[2023]版：
大类 | 3 区 医学
小类 | 4 区 肿瘤学 4 区 呼吸系统
第一作者：
第一作者机构： [1]Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [2]Institute of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [2]Institute of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [4]Precision Medicine Center, Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [5]Institute of Respiratory Health, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [6]The Research Units of West China, Chinese Academy of Medical Sciences, West China Hospital, Chengdu, Sichuan, China. [7]State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Chengdu, Sichuan, China.
推荐引用方式(GB/T 7714)：
Zhang Huohuo,Wu Jiaxuan,Gan Jiadi,et al.Proteomic Analysis of Plasma Exosomes Enables the Identification of Lung Cancer in Patients With Chronic Obstructive Pulmonary Disease[J].Thoracic Cancer.2025,16(1):e15517.doi:10.1111/1759-7714.15517.
APA：
Zhang Huohuo,Wu Jiaxuan,Gan Jiadi,Wang Wei,Liu Yi...&Li Weimin.(2025).Proteomic Analysis of Plasma Exosomes Enables the Identification of Lung Cancer in Patients With Chronic Obstructive Pulmonary Disease.Thoracic Cancer,16,(1)
MLA：
Zhang Huohuo,et al."Proteomic Analysis of Plasma Exosomes Enables the Identification of Lung Cancer in Patients With Chronic Obstructive Pulmonary Disease".Thoracic Cancer 16..1(2025):e15517

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