机构：[1]Department of Rehabilitation, School of Nursing, Jilin University, Changchun, China.[2]Department of Breast Surgery, Second Hospital of Jilin University, Changchun, China.[3]Rehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, China.四川大学华西医院
Research on the function of HGH1 in breast cancer remains lacking.TCGAand GEO (GSE45827) datasets investigated discrepancies in HGH1 expression in BC. An aggregate of 106 clinical samples were gathered through immunohistochemistry, KM curves were drawn for prognostic analysis, and the function of HGH1 of BC was predicted. Finally, the effects of HGH1 knockdown on MDA-MB-231 and MCF-7 BC cells were verified via CCK8, invasion, wound healing and colony formation assays.HGH1 is highly expressed in BC and is linked to unfavorable prognosis. HGH1 overexpression is connected to keratinization and the cell cycle and is closely related to ER and PR expression and tumor stage in BC patients. Knocking down HGH1 in BC cells inhibited the viability, invasion and migration.Knockdown of HGH1 in breast cancer cell lines can inhibit the viability, invasion and migration of tumor cells.
基金：
This study was supported by the Jilin Provincial Department of Science and Technology project (grant number: 20210204200YY) and the Healthcare Talents Program of the Finance Department of Jilin Province (grant number: 2024WSZX-B07).
语种：
外文
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出版当年[2025]版：
无
最新[2023]版：
大类|3 区生物学
小类|4 区细胞生物学
第一作者：
第一作者机构：[1]Department of Rehabilitation, School of Nursing, Jilin University, Changchun, China.
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推荐引用方式(GB/T 7714)：
Wang Zeyu,Liu Taiyuan,He Kang,et al.Knockdown of HGH1 in breast cancer cell lines can inhibit the viability, invasion and migration of tumor cells[J].Cell Adhesion & Migration.2025,19(1):1-14.doi:10.1080/19336918.2024.2442349.
APA：
Wang Zeyu,Liu Taiyuan,He Kang,Wang Longyun,Ma Xiaoxuan...&Zhao Lijing.(2025).Knockdown of HGH1 in breast cancer cell lines can inhibit the viability, invasion and migration of tumor cells.Cell Adhesion & Migration,19,(1)
MLA：
Wang Zeyu,et al."Knockdown of HGH1 in breast cancer cell lines can inhibit the viability, invasion and migration of tumor cells".Cell Adhesion & Migration 19..1(2025):1-14
