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Sialidase NEU3 silencing inhibits angiogenesis of EA.hy926 cells by regulating Wnt/β-catenin signaling pathway

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资源类型：
Pubmed体系：
作者：
Wu Yilun[1,2] * ; Yuan Xin[1,2] ; Zhang Yi[1,2] ; Ma Fang[1,2] ; Zhao Wei[5] ; Sun Xinrui[1,2] ; Ma Xue[3] ; Chen Yingjiao[4] ;
机构： [1]Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, China [2]Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan, 610041, China [3]Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China [4]Office for West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610021, China [5]Affiliated Hospital of Chengdu University, Chengdu, Sichuan, 637000, China
出处：
DOI： 10.1016/j.bbrc.2024.151098
ISSN：

关键词： Tumor angiogenesis Neuraminidase Sialidase Wnt/β-catenin signaling c-Myc Anti-angiogenic therapy

摘要：
Angiogenesis significantly drives tumor progression, and the functions of vascular endothelial cells are influenced by various factors. Tumor cells are characterized by abnormal sialylation, and their dynamic balance depends on sialyltransferases and sialidases. NEU3 is a plasma membrane-associated sialidase, vital for the regulation of cell surface sialylation. Our study revealed that, NEU3 is the most abundantly expressed among the four sialidase subtypes in EA.hy926 cells. Silencing NEU3 expression resulted in cell apoptosis and reduced proliferation, highlighting its crucial function in the regulation of cell activity. Subsequent experiments using transwell and tube formation assays demonstrated that the inhibition of NEU3 expression suppressed cell migration and angiogenesis. RNA sequencing analysis further elucidated that altering NEU3 expression in EA.hy926 cells impacts the Wnt/β-Catenin signaling pathway and c-Myc levels, thereby modulating cellular survival and migration capacity and exerting a regulatory effect on angiogenesis. These findings suggest that targeting NEU3 in the vascular endothelium may represent a promising strategy for anti-angiogenic therapy in tumors.Copyright © 2024. Published by Elsevier Inc.

基金：
Science and Technology Department of Sichuan Province (2023YFS0101) and the Sichuan Provincial Administration of Traditional Chinese Medicine (2023MS036).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
无
最新[2023]版：
大类 | 3 区 生物学
小类 | 3 区 生物物理 4 区 生化与分子生物学
第一作者：
第一作者机构： [1]Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, China [2]Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan, 610041, China
通讯作者：
推荐引用方式(GB/T 7714)：
Wu Yilun,Yuan Xin,Zhang Yi,et al.Sialidase NEU3 silencing inhibits angiogenesis of EA.hy926 cells by regulating Wnt/β-catenin signaling pathway[J].Biochemical And Biophysical Research Communications.2025,742:151098.doi:10.1016/j.bbrc.2024.151098.
APA：
Wu Yilun,Yuan Xin,Zhang Yi,Ma Fang,Zhao Wei...&Chen Yingjiao.(2025).Sialidase NEU3 silencing inhibits angiogenesis of EA.hy926 cells by regulating Wnt/β-catenin signaling pathway.Biochemical And Biophysical Research Communications,742,
MLA：
Wu Yilun,et al."Sialidase NEU3 silencing inhibits angiogenesis of EA.hy926 cells by regulating Wnt/β-catenin signaling pathway".Biochemical And Biophysical Research Communications 742.(2025):151098

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