机构：[1]The Second Department of Gastrointestinal Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China [2]Institute of Hepatobiliary, Pancreatic and Intestinal Disease, North Sichuan Medical College, Nanchong, Sichuan, China [3]Department of Gastroenterology, North Sichuan Medical College, Nanchong, Sichuan, China [4]Department of Gastrointestinal Surgery, The Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou, China [5]Anorectal Department of Integrated Traditional Chinese and Western Medicine, North Sichuan Medical College, Nanchong, Sichuan, China
We previously reported the oncogenic function of miR-92a in colorectal cancer. This study identified that miR-92a was upregulated in chemoresistant colorectal cancer cells and tissues. Ectopic expression of miR-92a conferred resistance to 5-fluorouracil-induced apoptosis in vitro, while antagomiR-92a significantly enhanced chemosensitivity in vivo. Moreover, Overexpression of miR-92a promoted the tumor sphere formation and the expression of stem cell markers. MiR-92a overexpression also displayed higher tumourigenesis in vivo. Furthermore, we demonstrated that miR-92a upregulates the Wnt/β-catenin signaling activity via directly targeting KLF4, GSK3β and DKK3, which are multiple level negative regulators of the Wnt/β-catenin signaling cascade. In addition, our results indicate IL-6/STAT3 pathway increases miR-92a expression by directly targeting its promoter, resulting in Wnt/β-catenin signaling activation and consequent promotion of stem-like phenotypes of colorectal cancer cells. Our present results suggest the essential role of IL-6/STAT3/miR-92a/Wnt/β-catenin pathway in regulating the stem cell-like traits of colorectal cancer cells and provide a potential target for colorectal cancer therapy.
基金：
Sichuan Youth Science and Technology Foundation (2017JQ0039), Scientific Research Project of Nanchong Municipal Science and Technology Bureau (16YFZJ0128), Scientific Research Project of Sichuan Medical Association (S15024), Scientific Research Project of Sichuan Provincial Health and Family Planning Commission (16ZD037), and Scientific Research Fund of Sichuan Provincial Education Department of China (14ZA0184, 13ZA0230).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|2 区医学
小类|2 区肿瘤学3 区细胞生物学
最新[2023]版：
无
第一作者：
第一作者机构：[1]The Second Department of Gastrointestinal Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China [2]Institute of Hepatobiliary, Pancreatic and Intestinal Disease, North Sichuan Medical College, Nanchong, Sichuan, China
共同第一作者：
通讯作者：
通讯机构：[1]The Second Department of Gastrointestinal Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China [2]Institute of Hepatobiliary, Pancreatic and Intestinal Disease, North Sichuan Medical College, Nanchong, Sichuan, China
推荐引用方式(GB/T 7714)：
Zhang Guang-Jun,Li Li-Fa,Yang Guo-Dong,et al.MiR-92a promotes stem cell-like properties by activating Wnt/β-catenin signaling in colorectal cancer.[J].Oncotarget.2017,8(60):101760-101770.doi:10.18632/oncotarget.21667.
APA：
Zhang Guang-Jun,Li Li-Fa,Yang Guo-Dong,Xia Shu-Sen,Wang Rong...&Zhou Tong.(2017).MiR-92a promotes stem cell-like properties by activating Wnt/β-catenin signaling in colorectal cancer..Oncotarget,8,(60)
MLA：
Zhang Guang-Jun,et al."MiR-92a promotes stem cell-like properties by activating Wnt/β-catenin signaling in colorectal cancer.".Oncotarget 8..60(2017):101760-101770
