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Impact of HA-PCI on self-reported cognitive functioning and brain metastases in small-cell lung cancer: Pooled findings of NCT01780675 and PREMER trials

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资源类型：
Pubmed体系：
作者：
Zeng Haiyan[1,2] * ; Schagen Sanne B[3] * ; Hendriks Lizza E L[4] ; Sanchez-Benavides Gonzalo[5,6] ; Jaspers Jaap P M[7] ; Manero Rosa Maria[8] ; Lievens Yolande[9] ; Murcia-Mejia Mauricio[10] ; Kuenen Marianne[3] ; Rico-Oses Mikel[11] ; Albers Elaine A C[3] ; Samper Pilar[12] ; Houben Ruud[2] ; de Ruiter Michiel B[3] ; Dieleman Edith M T[13] ; Lopez-Guerra Jose Luis[14,15] ; De Jaeger Katrien[16] ; Counago Felipe[17] ; Lambrecht Maarten[18] ; Calvo-Crespo Patricia[19] ; Belderbos Jose S.A.[20] ; De Ruysscher Dirk K M[2] ; Rodriguez de Dios Nuria[5,21,22] ;
机构： [1]Department of Radiation Oncology, Division of Thoracic Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China [2]GROW School for Oncology and Reproduction, Maastricht University Medical Centre+, Department of Radiation Oncology (Maastro), Maastricht, the Netherlands [3]Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Amsterdam, the Netherlands [4]GROW - School for Oncology and Reproduction, Maastricht University Medical Center+, Department of Pulmonary Diseases, Maastricht, the Netherlands [5]Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain [6]Barcelona Beta Brain Research Center (BBRC), Pasqual Maragall Foundation. Barcelona, Spain [7]Department of Radiotherapy, Erasmus MC Cancer Institute, Erasmus MC University Medical Center, Rotterdam, the Netherlands [8]Department of Neurology, Hospital del Mar, Barcelona, Spain [9]Ghent University Hospital and Ghent University, Radiation Oncology, Gent, Belgium [10]Department of Radiation Oncology, Hospital Universitario Sant Joan de Reus. Reus, Tarragona, Spain [11]Department of Radiation Oncology, Complejo Hospitalario Navarra, Pamplona, Spain [12]Department of Radiation Oncology. Hospital Universitario Rey Juan Carlos. Mostoles, ´ Madrid, Spain [13]Amsterdam UMC- Location AMC, Radiation Oncology, Amsterdam, the Netherlands [14]Radiation Oncology Unit, Instituto de Biomedicina de Sevilla, IBIS, Sevilla, Spain [15]Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain [16]Catharina Hospital, Radiation Oncology, Eindhoven, the Netherlands [17]Genesis Care Madrid Clinical Director. San Francisco de Asís and La Milagrosa Hospitals, Madrid, Spain [18]Department of Radiation Oncology, Leuven Cancer Institute, UZ Gasthuisberg, Leuven, Belgium [19]Department of Radiation Oncology, Hospital Universitario de Santiago de Compostela, Santiago de Compostela. A Coruna, [20]The Netherlands Cancer Institute, Antoni van Leeuwenhoek, Department of Radiation Oncology, Amsterdam, the Netherlands [21]Radiation Oncology, Hospital del Mar, Barcelona, Spain [22]Pompeu Fabra University, Barcelona, Spain
出处：
DOI： 10.1016/j.lungcan.2024.108036
ISSN：

关键词： Hippocampal avoidance-prophylactic cranial irradiation (HA-PCI) Self-reported cognitive functioning (SRCF) Brain metastases (BM) Small cell lung cancer (SCLC)

摘要：
Cognitive decline is an arising concern in patients who need cranial irradiation. We used the pooled longitudinal individual patient data of two phase III trials: NCT01780675 and PREMER to investigate whether hippocampal avoidance (HA)-PCI is associated with improved self-reported cognitive functioning (SRCF) compared with PCI without increasing brain metastases (BM) development within the HA area.Patients with stage I-IV small cell lung cancer (SCLC) were randomized to PCI or HA-PCI. SRCF was assessed and contrast enhanced brain magnetic resonance imaging (MRI) was performed at baseline and up to 24 months follow-up. SRCF and BM incidence after (HA)-PCI were compared between arms. Self reported cognitive impairment was defined as SCRF < 75.In total, 318 patients were randomized. Longitudinal generalized estimating equation (GEE) analysis showed that HA-PCI neither had a significant impact on SRCF (β = 1.41, p = 0.52) nor on cognitive impairment (OR 0.81, 95 %CI 0.53-1.25, p = 0.34). The median follow up was 41.7 (95 %CI 35.7-47.6) months, during which 61 patients developed BM (PCI arm: 30, HA-PCI arm: 31, p = 0.9). BM site was solitary in 15 patients (PCI arm: 7, HA-PCI arm: 8, p = 0.8). Nine of the 61 patients had BM within the HA area (PCI arm: 4, HA-PCI arm: 5, p = 1.0). The BM incidence was not significantly different between arms (subdistribution hazard ratio [sHR] 1.03, 95 %CI 0.62-1.70, p = 0.91).HA-PCI did not preserve longitudinal SRCF but did also not increase the risk of BM. Additional strategies should be investigated to further improve the therapeutic ratio of PCI.ClinicalTrials.gov (NCT01780675) ClinicalTrials.gov (NCT02397733).Copyright © 2024. Published by Elsevier B.V.

基金：
Scholarship of China Scholarship Council (Grant No.: CSC 201909370087), Sichuan Province’s Tianfu Emei Plan (Grant No.: 2548), KWF Kankerbestrijding (grant No.: NKI 2013-6096), Vlaamse Liga tegen Kanker, and IWT Agentschap voor Innovatie door Wetenschap en Technologie (grant No.: IWT-TBM-130262).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2024]版：
无
最新[2023]版：
大类 | 2 区 医学
小类 | 3 区 肿瘤学 3 区 呼吸系统
第一作者：
第一作者机构： [1]Department of Radiation Oncology, Division of Thoracic Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China [2]GROW School for Oncology and Reproduction, Maastricht University Medical Centre+, Department of Radiation Oncology (Maastro), Maastricht, the Netherlands
共同第一作者：
推荐引用方式(GB/T 7714)：
Zeng Haiyan,Schagen Sanne B,Hendriks Lizza E L,et al.Impact of HA-PCI on self-reported cognitive functioning and brain metastases in small-cell lung cancer: Pooled findings of NCT01780675 and PREMER trials[J].Lung Cancer (Amsterdam, Netherlands).2024,199:108036.doi:10.1016/j.lungcan.2024.108036.
APA：
Zeng Haiyan,Schagen Sanne B,Hendriks Lizza E L,Sanchez-Benavides Gonzalo,Jaspers Jaap P M...&Rodriguez de Dios Nuria.(2024).Impact of HA-PCI on self-reported cognitive functioning and brain metastases in small-cell lung cancer: Pooled findings of NCT01780675 and PREMER trials.Lung Cancer (Amsterdam, Netherlands),199,
MLA：
Zeng Haiyan,et al."Impact of HA-PCI on self-reported cognitive functioning and brain metastases in small-cell lung cancer: Pooled findings of NCT01780675 and PREMER trials".Lung Cancer (Amsterdam, Netherlands) 199.(2024):108036

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